From: Hereditary Colorectal Cancer Syndromes in Hong Kong: a Registry's Perspective
1. Families affected by histologically proven Familial Adenomatous Polyposis (FAP) or other polyposis syndrome. This includes index patients and at-risk first-degree relatives above the age of 12 years. |
2. Families affected by Hereditary Non-Polyposis Colorectal Cancer (HNPCC) satisfying the Amsterdam Criteria, the modified Amsterdam Criteria and/or with proven germline mismatch repair gene mutation. This includes index patients and at-risk first-degree relatives above the age of 25 years. |
3. Suspected HNPCC families satisfying one of the following criteria: |
   • An individual has histologically proven colorectal cancer diagnosed before the age of 45 years; |
   • An individual has two HNPCC-related cancers, including synchronous and metachronous colorectal cancer or associated extra-colonic cancers; |
   • An individual has histologically proven colorectal cancer and a first-degree relative has histologically proven colorectal cancer or HNPCC-related extra-colonic cancers. At least one of these cancers is diagnosed before the age of 45 years; |
   For these families, we recruit both index patients and at-risk first-degree relatives above an age five years younger than the youngest age of cancer diagnosis in the family; |
   Extra-colonic cancers include: cancers of the stomach, small bowel, uterus, ovary, brain and transitional cell carcinoma of the urological tract. |