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Table 3 Grouping of patients classified according to the site of APC mutation and colorectal phenotype. The numbers of patients with the expected phenotype at the respective germline mutation region are printed in bold

From: Familial Adenomatous Polyposis: Experience from a Study of 1164 Unrelated German Polyposis Patients

   Colorectal phenotype
Site of APC mutation (Codon) Predicted phenotype All patients known severe typical atypical attenuated unknown
122-161
314-405
1581-2557
Attenuated FAP 146 101   9 8 84 45
170-1578
without 1309
Typical FAP 1059 735 34 587 46 68 324
1309 Severe FAP 96 83 28 52 1 2 13
Large deletions ? 78 67   57 4 6 11
No mutation ? 687 540 12 123 52 353 147
All   2066 1526 74 828 111 513 540