Figure 1

Distribution of 597 germline point mutations and 37 large deletions in the APC gene detected in 634 out of 1166 unrelated FAP patients. A schematic diagram presents the promotor region (P) and the 15 exons of the APC gene. The black horizontal bars represent the extent of deletions as determined by MLPA, and the numbers on the left side of the bars indicate the deletions that have been identified more than once (details in [20]). The bar with dotted lines indicates a cytogenetically detectable deletion.