Table 1 Percentage of missense mutation variants identified in the Human Genome Database (to May 2005) [7]
From: Missense Mutations in Cancer Predisposing Genes: Can We Make Sense of Them?
Disease/mutation | Frequency of missense Mutation Variations |
|---|---|
Breast Cancer | 15.1% BRCA1 (99) |
| Â | 13.9% BRCA2 (62) |
FAP | 3.1% APC (19) |
HNPCC | 27.4% hMLH1 (102) |
| Â | 24.6% hMSH2 (75) |
| Â | 32.9% hMSH6 (23) |
PJS | 19.7% LKB1/STK11 (23) |
TOTAL | 403 missense variations |