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Table 1 Percentage of missense mutation variants identified in the Human Genome Database (to May 2005) [7]

From: Missense Mutations in Cancer Predisposing Genes: Can We Make Sense of Them?

Disease/mutation Frequency of missense Mutation Variations
Breast Cancer 15.1% BRCA1 (99)
  13.9% BRCA2 (62)
FAP 3.1% APC (19)
HNPCC 27.4% hMLH1 (102)
  24.6% hMSH2 (75)
  32.9% hMSH6 (23)
PJS 19.7% LKB1/STK11 (23)
TOTAL 403 missense variations