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Table 3 Clinical diagnostic criteria for hereditary breast and ovarian cancer

From: Clinical, Molecular and Geographical Features of Hereditary Breast/Ovarian Cancer in Latvia

HBC suspected (susp.) 1

HBC susp. 2

HBC

HBOC susp. 1

HBOC susp. 2

HBOC

One-case families

Two-case families

Three-case families

- at least one of the following criteria has to be met:

- one of the following criteria has to be met:

 

a) breast cancer diagnosed under the age of 40

a) two breast or two ovarian cancers among first degree relatives (or second through male) at any age

At least three breast or ovarian cancer patients on the same side of family diagnosed at any age; one of those patients is first degree relative (or second through male relative to other two)

b) medullary or atypical medullary breast cancer

  

c) male breast cancer

  

d) breast and ovarian cancer in the same individual at any age

b) one breast cancer diagnosed under the age of 50 and one ovarian cancer diagnosed at any age among first degree relatives (or second through male relatives)

 

e) bilateral breast cancer, one of them diagnosed under the age of 50