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Table 1 Genetic alterations identified in the MYH gene and disease characteristics of the patients

From: Frequency of the Common MYH Mutations (G382D and Y165C) in MMR Mutation Positive and Negative HNPCC Patients

Patient Number HNPCC MMR Mutation First Alteration Second Alteration Sex Age of Diagnosis of Adenomas Number of Adenomas CRC (Age of Diagnosis) Other Cancers
1 NO Y165C NO F 43 1 N-AF  
2 NO G382D V22M F >30 ? AF (36)  
3 hMSH2 (P)* G382D NO M 46 3 AF (46) Melanoma (42)
4 NO G382D NO M >70 ? N-AF Gastric (78)
5 hMSH2 G382D NO M >30 ? N-AF  
6 NO G382D V22M F >40 ? AF (47)  
7 NO G382D NO F 45 1 N-AF  
  1. * hMSH2 polymorphism with an unknown functional consequence