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Table 4 SIR for colorectal adenocarcinoma subsites in offspring by proband colorectal adenocarcinoma

From: The Swedish Family-Cancer Database: Update, Application to Colorectal Cancer and Clinical Relevance

   Proband subsite
Offspring Proband Right-sided colon Left-side colon All colon Rectum
   O1) SIR 95%CI O1) SIR 95%CI O SIR 95%CI O SIR 95%CI
Right-sided colon Parent 70 2.45 1.91 3.10 44 1.90 1.38 2.55 128 2.11 1.76 2.51 42 1.39 1.00 1.88
  Sibling 16 6.89 3.93 11.21 12 5.16 2.65 9.03 29 5.29 3.54 7.60 6 1.68 0.60 3.68
  Parent and sibling 4 34.62 9.00 89.52 0     6 16.04 5.77 35.14 1 10.66 0.00 61.11
Left-side colon Parent 51 1.85 1.38 2.44 48 2.15 1.58 2.85 113 1.94 1.60 2.34 52 1.79 1.33 2.34
  Sibling 10 4.56 2.17 8.41 4 1.81 0.47 4.68 15 2.89 1.61 4.77 9 2.66 1.20 5.06
  Parent and sibling 2 18.54 1.75 68.18 0     5 14.00 4.42 32.94 0    
All colon Parent 147 2.16 1.82 2.53 109 1.97 1.62 2.38 292 2.02 1.80 2.27 122 1.43 1.19 1.71
  Sibling 29 5.23 3.50 7.52 16 2.89 1.65 4.70 50 3.81 2.83 5.03 19 2.24 1.34 3.50
  Parent and sibling 6 21.94 7.90 48.06      12 13.39 6.88 23.46 1 3.65 0.00 20.94
Rectum Parent 69 1.54 1.20 1.95 58 1.59 1.21 2.05 156 1.64 1.39 1.92 84 1.77 1.41 2.19
  Sibling 5 1.38 0.43 3.24 9 2.43 1.10 4.64 18 2.09 1.23 3.31 11 1.96 0.97 3.51
  Parent and sibling 1 5.93 0.00 34.02 0     1 1.69 0.00 9.66 0    
  1. Bold type, 95% CI does not include 1.00.
  2. 1)Some observed numbers do not add up because in addition to the right- and left-sided colon cancer, multiple and unspecified colon tumours were included.