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Table 4 SIR for colorectal adenocarcinoma subsites in offspring by proband colorectal adenocarcinoma

From: The Swedish Family-Cancer Database: Update, Application to Colorectal Cancer and Clinical Relevance

  

Proband subsite

Offspring

Proband

Right-sided colon

Left-side colon

All colon

Rectum

  

O1)

SIR

95%CI

O1)

SIR

95%CI

O

SIR

95%CI

O

SIR

95%CI

Right-sided colon

Parent

70

2.45

1.91

3.10

44

1.90

1.38

2.55

128

2.11

1.76

2.51

42

1.39

1.00

1.88

 

Sibling

16

6.89

3.93

11.21

12

5.16

2.65

9.03

29

5.29

3.54

7.60

6

1.68

0.60

3.68

 

Parent and sibling

4

34.62

9.00

89.52

0

   

6

16.04

5.77

35.14

1

10.66

0.00

61.11

Left-side colon

Parent

51

1.85

1.38

2.44

48

2.15

1.58

2.85

113

1.94

1.60

2.34

52

1.79

1.33

2.34

 

Sibling

10

4.56

2.17

8.41

4

1.81

0.47

4.68

15

2.89

1.61

4.77

9

2.66

1.20

5.06

 

Parent and sibling

2

18.54

1.75

68.18

0

   

5

14.00

4.42

32.94

0

   

All colon

Parent

147

2.16

1.82

2.53

109

1.97

1.62

2.38

292

2.02

1.80

2.27

122

1.43

1.19

1.71

 

Sibling

29

5.23

3.50

7.52

16

2.89

1.65

4.70

50

3.81

2.83

5.03

19

2.24

1.34

3.50

 

Parent and sibling

6

21.94

7.90

48.06

    

12

13.39

6.88

23.46

1

3.65

0.00

20.94

Rectum

Parent

69

1.54

1.20

1.95

58

1.59

1.21

2.05

156

1.64

1.39

1.92

84

1.77

1.41

2.19

 

Sibling

5

1.38

0.43

3.24

9

2.43

1.10

4.64

18

2.09

1.23

3.31

11

1.96

0.97

3.51

 

Parent and sibling

1

5.93

0.00

34.02

0

   

1

1.69

0.00

9.66

0

   
  1. Bold type, 95% CI does not include 1.00.
  2. 1)Some observed numbers do not add up because in addition to the right- and left-sided colon cancer, multiple and unspecified colon tumours were included.
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287