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Table 3 SIR for offspring CRC depending on the CRC in probands

From: The Swedish Family-Cancer Database: Update, Application to Colorectal Cancer and Clinical Relevance

Familial cancer site

Parent only

Sibling only

Parent and Sibling

 

O1)

E

SIR

95%CI

O1)

E

SIR

95%CI

O

E

SIR

95%CI

Colon

448

239.40

1.87

1.70

2.05

68

21.70

3.13

2.43

3.97

13

1.50

8.73

4.63

14.97

Rectum

227

141.30

1.61

1.40

1.83

30

14.10

2.13

1.44

3.04

1

0.40

2.24

0.00

12.81

Colorectum

664

376.30

1.76

1.63

1.90

93

34.30

2.71

2.19

3.32

17

3.30

5.08

2.95

8.16

  1. Bold type, 95% CI does not include 1.00.
  2. 1)Some observed numbers do not add up because in addition to the right- and left-sided colon cancer, multiple and unspecified colon tumours were included.
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287