Table 1 The variable expression of MEN1. Percentages of MEN1 germline mutation carriers that develop a MEN1-associated tumour. ACTH: adrenocorticotrophic hormone
From: Diagnosis and Management of Multiple Endocrine Neoplasia Type 1 (MEN1)
Parathyroid adenomas | 75-95% |
Pancreatic islet cell tumours | 70% |
   Gastrinomas | 45% |
   Insulinomas | 10% |
   Non-functioning (including pancreatic polypeptide producing tumours) | 10% |
   Other | 2% |
Pituitary adenomas | 47% |
   Prolactinomas | 30% |
   Non-functioning (i.e. not producing hormone) | 10% |
   ACTH producing | 1% |
   GH producing | 3-6% |
Adrenal adenomas | 20% |
Carcinoid tumours | 18% |
   Thymus | 8% |
   Bronchial | 8% |
   Stomach | 5% |
Skin lesions | 80% |
   Angiofibromas | 75% |
   Collagenomas | 5% |
Lipomas | 30% |
Leiomyomas | 5% |