Skip to main content

Advertisement

Table 1 Cumulative risk of breast cancer in Sweden, penetrance of BRCA1 and BRCA2 mutations based on the literature and life expectancy of Swedish women*

From: Contribution of the Defective BRCA1, BRCA2 and CHEK2 Genes to the Familial Aggregation of Breast Cancer: a Simulation Study Based on the Swedish Family-Cancer Database

  Cumulative risk of breast cancer (%) % alive
by age all women BRCA1 mutation carriers BRCA2 mutation carriers  
25 0.003 0.10 0.10 99.1
30 0.02 0.65 0.70 98.8
35 0.09 4.26 2.47 98.4
40 0.31 11.57 6.20 97.7
45 0.85 23.59 10.37 96.5
50 1.74 38.31 16.18 94.3
55 2.95 45.96 23.05 90.5
60 4.26 53.51 30.55 85.9
65 5.59 59.38 38.61 80.5
69 6.48 62.73 42.25 77.3
  1. *[12]; see Patients and methods for details