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Table 5 Cost analysis using preselection by clinical criteria and IHC and/or MSI analysis for cases where all three tests could be applied

From: Economic and Practical Factors in Diagnosing HNPCC Using Clinical Criteria, Immunohistochemistry and Microsatellite Instability Analysis

 

Method of preselection (no of cases studied)

Total cases selected for testing

No of genes

Total tests

Total mutations detected

Mutations missed by selecting

Cost per mutation detected (euros)

 

1

AC

53

2

106

30

19

1 767

1

 

MA

65

2

130

37

12

1 844

 
 

B1-3

99

2

198

45

4

2 200

 
 

B

136

2

272

49

0

2 776

 
 

Any CC

138

2

276

49

0

2 816

 

2

AC+IHC (23)

12

1

12

10

9

715

2

 

MA+IHC (24)

13

1

13

10

9

770

 
 

B1-3+IHC (42)

20

1

20

14

5

864

 
 

B+IHC (63)

28

1

28

16

3

1 072

 
 

Any CC+IHC (64)

28

1

28

16

3

1 075

 

3

AC+MSI (24)

11

2

22

8

5

1 525

3

 

MA+MSI (25)

11

2

22

8

5

1 531

 
 

B1-3+MSI (40)

18

2

36

13

5

1 666

 
 

B+MSI (59)

23

2

46

13

6

1 996

 
 

All CC+MSI (60)

23

2

46

13

6

2 000

 

4

A+IHC+MSI (21)

11

2

1

2

15

10

6

855

 
 

MA+IHC+MSI (22)

12

2

1

2

16

10

6

910

 
 

B1-3+IHC+MSI (36)

16

5

1

2

26

14

2

1 057

 
 

B+IHC+MSI (54)

24

6

1

2

36

16

0

1 294

 
 

All CC+IHC+MSI (55)

24

6

1

2

36

16

0

1 297

 
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