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Table 2 Clinical, pathological and molecular parameters of breast tumours in 13964 G>C carriers

From: Intronic TP53 Germline Sequence Variants Modify the Risk in German Breast/Ovarian Cancer Families

Patients Age at diagnosis of breast cancer Histologya UICCbstage, grade of malignancy % of TP53 positively stained cell nucleicTumour tissue/Normal tissue
Sporadic     
   R670 63 IDC IIIA, G3 100/0
   R688 68 IDC I, G3 0/0
   R728 59 IDC I, G3 0/0
   R729 50 IDC IIA, G3 0/0
Familial     
   26/III: 1 34 IDC I, G2 not available
   26/III: 2 36 IDC IIB, G3 0/0
   P328/II: 5 67 IDC I, G3 0/0
   P328/III: 5 51 IDC+ILC IIB, G2 0/0
  1. a IDC = invasive ductal carcinoma, ILC = invasive lobular carcinoma.
  2. b According to UICC (1997) [40].
  3. c Nuclear expression of TP53 protein was assessed by immunohistochemistry.