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Table 1 Characteristics and TP53 sequence variants in German breast/ovarian cancer families

From: Intronic TP53 Germline Sequence Variants Modify the Risk in German Breast/Ovarian Cancer Families

Family No. of breast cancers (age at diagnosis) No. of ovarian cancers Other cancers (age at diagnosis) TP53 mutation
19 6 (38,39,45,45,49,50) 2 Lung (<45), 2× liver, vulva, colon (39), fallopian tube (49) IVS6, 13964 G>C
26 3 (34,36,44) 0 Hodgkin's disease (22) IVS6, 13964 G>C
P328 a 3 (34,51,67) 0 5× prostate (52,59,70,75, <84), skin (43) IVS6, 13964 G>C
89 5 (40,45,48,51,70) 0 Cervix, colon, cancer of unknown type IVS10, 17708 A>T
128 5 (30,45,52,53,64) b 0 Brain, stomach/lung IVS10, 17708 A>T
P313 3 (43, 47) c 0 Malignant melanoma (51), sarcoma (61) IVS10, 17708 A>T
  1. a Family P328 also carries a Tyr179Cys missense mutation of the BRCA1 gene. This mutation was described 35 times previously to the BIC database (39).
  2. b Including a male breast cancer.
  3. c One patient's age at diagnosis is unknown.