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Table 1 Reported familial risks and heritability of cervical cancer

From: Familial Cervical Cancer: Case Reports, Review and Clinical Implications

Author Type of study Number of patients Number of controls Risk for first degree relative to develop CIN/CIS/CC Comments Heritability (%)
Furgyik
et al. [20]
case-control relatives of 180 CIS/CC patients relatives of 105
male consorts
7.9% vs. 1.1% (p < 0.01)
7.5% vs. 1.0% (p < 0.01)
15.6%
% of mothers with CIS/CC
% of sisters with CIS/CC
% of mothers and/or sisters with CIS/CC
 
Brinton
et al. [18]
case-control 418 SCC patients
23 ASC patients
40 AC patients
801 healthy women OR = 3.1 (p <0.05)
OR = 9.9 (p <0.05)
OR = 2.49 (N.S.)
family history of CC in patients vs. controls  
Ahlbom
et al. [13]
longitudinal
cohort study
twin study
263 MZ twins
395 DZ twins
MZ vs. DZ
-
-
RR = 4.8 (95% CI 3.0-7.6)
RR = 2.4 (95% CI 1.5-3.8)
RR = 2.0 (95% CI 1.1-3.5)
risk for twin sister to develop CIS
risk for twin sister to develop CIS
comparing MZ and DZ twins
39-46%
Hemminki
et al. [12]
longitudinal
cohort study
relatives of 125,569
CIS patients
relatives of 13,982
CC patients
relatives of 3,901,140
healthy women
FRR = 1.79 (95% CI 1.75-1.84)
FRR = 2.30 (95% CI 1.66-2.93)
risk for daughters of patients vs. daughters of healthy women to develop CIS
risk for daughters of patients vs. daughters of healthy women to develop CC
11-15% (CIS)
22-34% (CC)
Magnusson
et al. [21]
nested
case-control
study
in cohort study
relatives of 71,533
CIN/CIS/CC patients
relatives of 194,810
healthy women
FRR = 1.83 (95% CI 1.77-1.88)
vs. FRR = 1.10 (95% CI 0.76-1.54)
FRR = 1.93 (95% CI 1.85-2.01)
vs. FRR = 1.15 (95% CI 0.82-1.57)
FRR = 1.45 (95% CI 1.31-1.60)
risk for biologic vs. adoptive mothers
risk for biologic vs. adoptive sisters
risk for half-sisters (same mother or same father)
-
Magnusson
et al. [14]
longitudinal
cohort study
relatives of 65,685
CIN/CIS/CC patients
relatives of 189,635
healthy women
- - 27%
Hemminki
et al. [22]
longitudinal
cohort study
relatives of 191,081
CIS patients
relatives of 21,727
CC patients
relatives of 5,935,132
healthy women
RR = 1.51-1.77 (95% CI 1.33-2.10)
RR = 1.73-2.12 (95% CI 1.37-3.17)
risk for relatives of patients
vs. relatives of healthy women
 
Fischer et al. [19] Longitudinal cohort study relatives of 893 CC patients - 6.9% % of relatives with CC  
  1. OR = odds ratio
  2. RR = relative risk = the risk of cases compared with the risk of control
  3. FRR = familial relative risk = the risk to the relatives of cases divided by the risk to the relatives of controls
  4. Heritability = the proportion of total variance due to genetic variance
  5. MZ = monozygotic
  6. DZ = dizygotic
  7. CIN = cervical intra-epithelial neoplasia
  8. CIS = carcinoma in situ
  9. CC = cervical cancer
  10. SCC = squamous cell carcinoma
  11. ASC = adenosquamous carcinoma
  12. AC = adenocarcinoma