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Table 6 Missense changes identified in exon 15 of the APC gene

From: Germline Missense Changes in the APC Gene and Their Relationship to Disease

Exon

Nucleotide

Codon

Reported in Human Genome Database

Number of observations

New

15.5

3386 T>C

L1129S

No

2

Yes

15.7

3949 G>C

E1317Q

Yes

2

No

15.8

4237 A>G*

M1413V

No

1

Yes

15.10

4918 C>T

R1640W

Yes

1

No

15.12

5465 A>T*

D1822V

Yes

23

No

15.19

7406 C>T*

S2469F

No

2

Yes

15.19

7504 G>A*

G2502S

No

3

Yes

15.20

7862 C>G

S2621C

Yes

2

No

15.21

8068 G>A

A2696T

No

1

Yes

  1. *Causative mutation identified in patients harbouring these missense changes