Table 6 Candidate genes analysed in gastric cancer families
Candidate gene | No of families analysed | Germline mutations | Observations | Reference |
|---|---|---|---|---|
TP53 | 66 | 471C>G (FGC) 847C>T (FDGC) | Family reclassified as Li-Fraumeni Highly conserved residue (Arg 283) | Oliveira et al, in press [30] Keller et al, 2004 [29] |
SMAD4 | 32 | 0 | Probably not relevant for familial gastric cancer | Oliveira et al, in press [30] |
Caspase10 | 32 | 0 | Probably not relevant for familial gastric cancer | Oliveira et al, in press [30] |
RUNX3 | 34 | 0 | Probably not relevant for familial gastric cancer | Keller et al, 2004 [29] |
HPP1 | 34 | 0 | Probably not relevant for familial gastric cancer | Keller et al, 2004 [29] |