Skip to main content

Table 5 Polymorphisms identified in CDH1 in gastric cancer probands and normal controls reported to date

From: Genetic Screening for Familial Gastric Cancer

Sequence variant

Gene location

Codon

Effect

% patients

% controls

Reference

-71C>G

Promoter

 

Unknown

1/13 (7.7%)

2/51 (3.9%)

Avizienyte et al, 2000 [87]

-160C>A

Promoter

 

See text

17/32 (53.1%)

63/114 (55.3%)

Oliveira et al, 2002 [32]

    

2/5 (40%)

38/94 (40.4%)

Humar et al, 2002 [89]

    

7/28 (25%)

32/142 (22.5%)

Shin et al, 2004 [39]

    

31/87 (35.6%)

18/50 (36%)

Wang et al, 2003 [27]

-347G>GA

Promoter

 

See text

12/28 (42.9%)

39/142 (27.5%)

Shin et al, 2004 [39]

48+6T>C

Intron 1

 

Unknown

5/13 (38%)

18/51 (35%)

Avizienyte et al, 2000 [87]

    

11/28 (39.3%)

27/100 (27%)

Oliveira et al, 2002 [32]

    

1/10 (10%)

75/350 (21.4%)

Humar et al, 2002 [89]

    

5/17 (29.4%)

nd

Yabuta et al, 2002 [26]

531+10G>C

Intron 4

 

Unknown

2/34 (5.9%)

nd

Oliveira et al, 2002 [32]

    

ns

nd

Guilford et al, 1999 [12]

    

ns

nd

Gayther et al, 1998 [10]

532-18C>T

Intron 4

 

Unknown

2/66 (3.0%)

0/100 (0%)

Suriano and Oliveira et al, 2003 [33]

    

2/34 (5.9%)

1/50 (2.0%)

Keller et al, 2004 [29]

918C>T

Exon 7

306

Silent

1/34 (2.9%)

nd

Oliveira et al, 2002 [32]

1029C>G

Exon 8

343

Silent

1/34 (2.9%)

nd

Oliveira et al, 2002 [32]

1774G>A

Exon 12

592

A592T

1/34 (2.9%)

1/50 (2.0%)

Keller et al, 2004 [29]

1849G>A

Exon 12

617

A617T

2/66 (3%)

2/193 (1%)

Suriano and Oliveira et al, 2004 [33]

1896C>T

Exon 12

632

Silent

1/34 (2.9%)

5/100 (5%)

Oliveira et al, 2002 [32]

    

ns

nd

Gayther et al, 1998 [10]

1937-13T>C

Intron 12

 

Unknown

2/27 (7.4%)

25/100 (25%)

Oliveira et al, 2002 [32]

    

ns

nd

Guilford et al, 1998, 1999 [9, 12]

1937-27T>G

Intron 12

 

Unknown

ns

nd

Guilford et al, 1999 [12]

2076C>T

Exon 13

692

Silent

8/13 (61.5%)

nd

Avizienyte et al, 2000 [87]

    

15/27 (55.6%)

29/100 (59.0%)

Oliveira et al, 2002 [32]

    

1/5 (20%)

nd

Richards et al, 1999 [11]

    

7/16 (43.8%)

nd

Iida et al, 1999 [86]

    

ns

nd

Guilford et al, 1998, 1999 [9, 12]

    

ns

nd

Gayther et al, 1998 [10]

    

ns

ns

Yabuta et al, 2002 [26]

    

82/87 (94.3%)

48/50 (96%)

Wang et al, 2003 [27]

2253C>T

Exon 14

751

Silent

ns

ns

Yabuta et al, 2002 [26]

2292C>T

Exon 14

764

Silent

1/34 (2.9%)

nd

Oliveira et al, 2002 [32]

2634C>T

Exon 16

878

Silent

1/34 (2.9%)

nd

Oliveira et al, 2002 [32]

  1. nd, Not done; ns, Not specified.