Table 4 Functional characterization of missense mutations found in gastric cancer probands
CDH1 Construct | Aggregation | Invasion | Pathogenic significance |
|---|---|---|---|
Wild type | Yes | No | Not applicable |
A298T | No | Yes | Yes |
T340A | No | Yes | Yes |
W409R | No | Yes | Yes |
A592T | Yes | No | No |
A617T | Yes | No | No |
A634V | No | Yes | Yes |
R732Q | No | Yes | Yes |
P799R | No | Yes | Yes |
V832M | No | Yes | Yes |