From: Towards Evidence-Based Management of Inherited Breast and Breast-Ovarian Cancer
BRCA1 mutation carriers (by testing or assumed by family history) |
---|
1. Annual clinical mammography and MRI from the age of 30 years onwards. For demonstrated mutation carriers there should be no upper age limit. Healthy at-risk women based on family history alone will have low probability for being mutation carriers over 70 years of age. |
2. Prophylactic mastectomy should be an option, but may not be actively advocated until the benefit of MRI is known. |
3. Prophylactic oophorectomy over 35 years of age when family is completed. |
BRCA2 mutation carriers (by testing or assumed by family history) |
1. As for BRCA1 mutation carriers, but oophorectomy may not be indicated before 40 years of age. |
2. There is no consensus on practical use, but anti-oestrogens may prevent oestrogen receptor-positive tumours. |
Familial breast cancer (high breast cancer risk according to family history not including ovarian cancer) |
1. Annual clinical mammography from the age of 30 years onwards. |
2. There is no consensus on practical use, but anti-oestrogens may prevent oestrogen receptor-positive tumours. |