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Hereditary Cancer in Clinical Practice

Open Access

Retrospective analysis of patients with hereditary non- polyposis colorectal cancer (HNPCC)

  • Banaszkiewicz Zbigniew1Email author,
  • Pawel Jarmocik1,
  • Marcin Mrozowski1 and
  • Arkadiusz Jawien1
Hereditary Cancer in Clinical Practice201513(Suppl 1):A8

Published: 9 September 2015

Retrospective analysis of patients with hereditary non-polyposis colorectal cancer (HNPCC)

We performed a one–center cohort retrospective analysis of 1378 non-selected patients operated for colorectal cancer (CRC) in the years 1994 – 2013. For the purpose of this study we divided patients into three subdivisions reflecting their family history of HNPCC–associated cancers among first- and second-degree relatives. On detailed pedigree analysis of the families we identified 59 patients as being affected with HNPCC (4.28%). To compare with other CRC patients our HNPCC subjects were significantly younger at time of diagnosis (median age 51 years, p < 0.05), presented more likely with right–sided tumors rather than with rectal ones (p < 0.05). Synchronous tumors were the case in 45 CRC patients (3.27%), of whom HNPCC subjects were predominant (8.47 vs. 3.03%, p= 0.02). HNPCC patients were also more likely to receive radical resection surgery compared with other CRC patients (93.22% vs. 86.73%). Patients with HNPCC presented with more favorable staging and more frequent mucinous component on histological examination. Overall survival was statistically longer in HNPCC than in other CRC patients (45 vs. 25 months, p =0.01806). Submitted data and our experience in colorectal surgery made us to support conclusion corroborated by literature evidence and regarding fine distinction between HNPCC and sporadic CRC patients.

Authors’ Affiliations

Department ofGeneral, Gastrointestinal, Colorectal, and Oncology Surgery, Department and Clinic ofVascular Surgeryand Angiology, University Hospital 2, Bydgoszcz, Poland


© Banaszkiewicz et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.