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Pericardial metastases from BRCA1-associated peritoneal cancer. Case report

Women with BRCA1 gene mutations have about 30 to 40 times higher risk of ovarian cancer compared to the population risk (the lifetime risk of BRCA1-dependent ovarian cancer is about 40 percent). Because of the high risk BRCA1 mutations carriers at the age of about 40 are recommended prophylactic salpingo-oophorectomy (after completion of reproductive plans). After the surgery there is still a risk of peritoneal cancer which histologically resembles ovarian cancer, but it is much lower than the risk of ovarian cancer before salpingo-oophorectomy: the cumulative risk of developing cancer of the peritoneum is about 4 percent during 20 years from the removal of ovaries and fallopian tubes.

We are going to present a case of long lasting diagnosis of pericardial metastases from BRCA1-associated peritoneal cancer.

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Correspondence to Anna Abramowska.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Abramowska, A., Godlewski, D. Pericardial metastases from BRCA1-associated peritoneal cancer. Case report. Hered Cancer Clin Pract 13, A17 (2015). https://doi.org/10.1186/1897-4287-13-S1-A17

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Keywords

  • Public Health
  • High Risk
  • Ovarian Cancer
  • Cancer Research
  • Gene Mutation