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Table 2 Patient criteria for genetic testing according to NCCN clinical practice guidelines in oncology v.1.2010 [21] for HBOC

From: TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer families

Patient 1

Patient 2

Criteria

 

X

Personal history of breast cancer ≤ 45 years

  

Personal history of two primary breast cancers, the first being diagnosed before 50 years of age

  

Personal history of breast cancer with age at diagnosis < 50 years with limited family history

 

X

Personal history of breast cancer ≤ 50 years with ≥ 1 relative with breast cancer ≤ 50 years and/or ≥ 1 relative with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer at any age

  

Personal history of triple-negative breast cancer, with age at diagnosis < 60 years

X

 

Personal history of breast cancer at any age, with ≥ 2 relatives with breast cancer and/or epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer at any age

  

Personal history of breast cancer + Personal history of epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer