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Table 2 Frequency of missing teeth between cases and controls

From: Colorectal cancer and self-reported tooth agenesis

 

Cases

Controls

p value

 

n/N (%)

n/N (%)

 

Total

78/1636 (4.8%)

158/2788 (5.7%)

0.20

Recruitment site

   

Ontario

51/928 (5.5%)

88/1484 (5.9%)

0.66

Mayo Clinic

27/708 (3.8%)

70/1304 (5.4%)

0.12

Gender

   

Male

20/695 (2.9%)

47/1094 (4.3%)

0.12

Female

58/941 (6.2%)

111/1694 (6.6%)

0.70

Mutation status*

   

MLH1

1/63 (1.6%)

2/19 (10.5%)

0.13

MSH2

6/72 (8.3%)

3/35 (8.6%)

0.99

MSH6

0/8 (0%)

2/5 (40%)

0.13

PMS2

0/10 (0%)

0/6 (0%)

NA

All MMR genes

7/153 (4.6%)

7/65 (10.8%)

0.13

MUTYH

0/23 (0%)

1/24 (4.2%)

0.99

  1. n = number of study participants with missing teeth.
  2. N = total number of study participants.
  3. *The germline status of these genes was available in the Colon Cancer Family Registry. These genes are not suspected of being involved with dental formation but were included in a stratified analysis just to be certain they were not contributing to the phenotype.