Table 3 Prevalence of the examined mutations/polymorphisms among DD cases and healthy controls

BRCA1/5382insC

2/496 = 0,40%

1/496 = 0,19%

0,5346

2,105

BRCA1/4153delA

3/496 = 0,60%

0/496 = 0%

BRCA1/C61G

0/521 = 0%

1/521 = 0,19%

CHK2/I157T

30/505 = 5,94%

26/505 = 5,15%

0,5416

1,183

CHK2/CHIVS2

5/505 0,99%

4/512 = 0,78%

0,7222

1,270

NOD2/3020insC

43/505 8,51%

45/493 = 9,13%

0,7328

0,9266

XPD/936 (D312M)

TT 160/504 31,75%

TT 196/484 = 40,49%

-

-

CT 193/504 = 38,29%

CT 193/484 = 39,88%

0,6103

0,9357

CC 151/504 = 29,96%

CC 95/484 = 19,63%

0,004*

1,752

XPD/2253 (K751Q)

AA 152/503 = 30,22%

AA 191/524 = 36,45%

-

-

AC 268/503 = 53,28%

AC 245/524 = 46,76%

0,732*

1,299

CC 83/503 = 16,50%

CC 88/524 = 16,79%

0,8998

0,9791

MC1R/R151C

CC 455/500 = 91,00%

CC 453/500 = 90,60%

-

-

CT 44/500 = 8,80%

CT 45/500 = 9,00%

0,9116

0,9756

TT 1/500 = 0,20%

TT 2/500 = 0,40%

0,5631

0,4990

MC1R/V60L

GG 427/499 = 85,57%

GG 454/512 = 88,67%

-

-

GT 68/499 = 13,63%

GT 53/512 = 10,35%

0,1087

1,366

TT 4/499 = 0,80%

TT 5/512 = 0,98%

0,7672

0,8194

MC1R/R163Q

GG 460/499 = 92,18%

GG 463/503 = 92,05%

-

-

AG 39/499 = 7,82%

AG 37/503 = 7,35%

0,7834

1,068

AA 0/499 = 0%

AA 3/503 = 0,60%

0,0840

0,1431

VDR/M1T

GG 135/504 = 26,79%

GG 161/518 = 31,08%

-

-

AG 277/504 = 54,96%

AG 262/518 = 50,58%

0,1607

1,192

AA 92/504 = 18,25%

AA 95/518 = 18,34%

0,9717

0,9943

CDKN2A/A148T

25/504 = 4,96%

23/490 = 4,69%

0,8447

1,060

p53/P72R

GG 260/496 = 52,42%

GG 269/513 = 52,44%

-

-

CG 188/496 = 37,90%

CG 210/513 = 40,93%

0,3245

0,8807

CC 48/496 = 9,68%

CC 34/513 = 6,63%

0,0763

1,509

rs6983267

GG 122/500 = 24,40%

GG 135/519 = 26,01%

-

-

GT 262/500 = 52,40%

GT 260/519 = 50,10%

0,4621

1,097

TT 116/500 = 23,20%

TT 124/519 = 23,89%

0,7946

0,9623

ATM/E1978X

1/505 = 0,20%

0/505 = 0%

NA

NA

MTHFR/(A222V

CC 191/415 = 46,02%

CC 229/500 = 45,80%

-

-

CT 185/415 = 44,58%

CT 227/500 = 45,40%

0,8036

0,9673

TT 39/415 = 9,40%

TT 44/500 = 8,80%

0,7540

1,075

XPC/A499V

GG 299/489 = 61,15%

CC 258/489 = 52,7%

-

-

AG 167/489 = 34,15%

CT 194/489 = 39,6%

0,2083

0,8679

AA 23/489 = 4,70%

TT 33/489 = 6,70%

0,3245

0,7098

XPD/rs238406

(c.396A > C)

CC 173/492 = 35,16%

CC 141/492 = 28,66%

-

-

AC 230/492 = 46,75%

AC 267/492 = 54,27%

0,098*

0,7407

AA 89/492 = 18,09%

AA 84/492 = 17,07%

0,5994

1,076

XPF/rs762521

(c.207 + 11G > A)

GG 266/478 = 55,65%

GG 280/478 = 58,57%

-

-

AG 182/478 = 38,07%

AG 167/478 = 34,94%

0,2083

1,150

AA 30/478 = 6,28%

AA 31/478 = 6,49%

0,8696

0,9644