Table 2 Expected and observed frequencies, related risk of occurrence of malignancies of different site of origin in Dupuytren’s disease families
From: Dupuytren’s disease and the risk of malignant neoplasms
Tumor site | Gender | Observed | Expected | Relative risk (RR), p-value | Statistical power** |
|---|---|---|---|---|---|
cases | cases | ||||
Breast | Females | 40 | 33 | 1.212, p = 0.5080 | 0,04 |
Lungs | Males | 36 | 29 | 1.241, p = 0.4516 | 0,002 |
Females | 6 | 13 | 0.462, p = 0.1670 | 0,06 | |
Colorectal | Males | 22 | 28 | 0.786, p = 0.4756 | 0,09 |
Females | 11 | 15 | 0.733, p = 0.5542 | 0,007 | |
Stomach | Males | 17 | 7 | 2.429, p = 0.651 | 0,08 |
Females | 5 | 4 | 1.250, p = 1.0000 | 0,004 | |
Melanoma | Males | 2 | 2 | 1.000, p = 0.6168 | 0,002 |
Females | 1 | 3 | 0.333, p = 0.6168 | 0,02 | |
Kidney | Males | 5 | 6 | 0.833, p = 1.0000 | 0,008 |
Females | 6 | 4 | 1.500, p = 0.7513 | 0,01 | |
Prostate | Males | 23 | 18 | 1.278, p = 0.5292 | 0,003 |
Larynx | Males | 11 | 4 | 2.750, p = 0.1204 | 0,05 |
Females | 0 | 1 | NA | 0,05 | |
CNS | Males | 13 | 1 | 12.00, p = 0.0704* | 0,81 |
Females | 11 | 1 | 11.00, p = 0.2392* | 0,65 | |
Leukaemia | Males | 5 | 3 | 1.667, p = 0.7233 | 0,004 |
Females | 4 | 3 | 1.333, p = 1.0000 | 0,005 | |
Brain | Males | 2 | 3 | 0.667, p = 1.0000 | 0,009 |
Females | 4 | 3 | 1.333, p = 1.0000 | 0,005 | |
Bones | Males | 3 | 0,3 | NA | 0,06 |
Females | 1 | 0,3 | NA | 0,008 | |
Bladder | Males | 4 | 10 | 0.400, p = 0.0953 | 0,16 |
Females | 2 | 3 | 0.667, p = 1.0000 | 0,004 | |
NHL | Males | 4 | 2 | 2.000, p = 0.6828 | 0,006 |
Females | 2 | 2 | 1.000, p = 0.6168 | 0,002 | |
Pancreas | Males | 4 | 3 | 1.333, p = 1.0000 | 0,003 |
Females | 7 | 3 | 2.333, p = 0.3418 | 0,05 | |
Uterus | Females | 6 | 11 | 0.546, p = 0.3303 | 0,09 |
Ovary | Females | 4 | 8 | 0.500, p = 0.3853 | 0,03 |
Thyroid | Males | 5 | 2 | 2.267, p = 0.2202 | 0,02 |
Females | 1 | 4 | 0.250, p = 0.3701 | 0,04 | |
Cervix | Females | 4 | 4 | 1.000, p = 0.4793 | 0,002 |
Non-melanoma skin cancer | Males | 6 | 9 | 0.667, p = 0.6046 | 0,03 |
Females | 2 | 11 | 0.182, p = 0.6786* | 0,33 | |
Esophagus | Males | 1 | 2 | 0.500, p = 0.9994 | 0,02 |
Females | 1 | 0,5 | NA | 0,004 | |
Gallbladder | Males | 1 | 0,4 | NA | 0,004 |
Females | 0 | 2 | NA | 0,14 | |
Liver | Males | 2 | 2 | 1.000, p = 0.6168 | 0,003 |
Females | 2 | 1 | 2.000, p = 1.0000 | 0,007 | |
HL | Males | 0 | 1 | NA | 0,06 |
Females | 1 | 1 | 1.000, p = 0.4793 | 0,002 | |
Multiple myeloma | Males | 0 | 1 | NA | 0,06 |
Females | 1 | 1 | 1.000, p = 0.4793 | 0,002 | |
Testicle | Males | 1 | 2 | 0.500, p = 1.0000 | 0,02 |