No family history | One affected relative | Two or more affected relatives | |
---|---|---|---|
Prevalence of CDKN2A pathogenic mutation | |||
One primary only | 1.1% (27/2495) | 3.8% (7/185) | 20.0% (8/40) |
Two primaries | 3.6% (5/140) | 14.3% (3/21) | 33.3% (2/6) |
Three or more primaries | 26.7% (8/30) | 20.0% (1/5) | 60.0% (3/5) |
Odds ratios 1 and 95% confidence intervals | |||
One primary only | 1 (reference) | 3.3 (1.4, 7.7) | 18.9 (7.8, 45.5) |
Two primaries | 3.5 (1.3, 9.3) | 13.1 (3.6, 47.8) | 42.7 (7.5, 244.0) |
Three or more primaries | 33.1 (13.5, 81.5) | 23.8 (2.6, 221.2) | 146.6 (23.1, 928.1) |