Table 4 Association of family history and number of primaries with prevalence of CDKN2A mutations
Australia | Spain | UK | Total | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Predictor | No./total cases1 | % | OR2(95% CI) | No./total cases | % | OR (95% CI) | No./total cases | % | OR (95% CI) | % | Multivariate OR3 |
Family history 4 | |||||||||||
0 | 7/500 | 1.4 | 1.0 | 13/696 | 1.9 | 1.0 | 20/1470 | 1.4 | 1.0 | 1.5 | 1.0 |
1 | 4/76 | 5.3 | 3.9 (1.1, 13.7) | 3/35 | 8.6 | 4.9 (1.3, 18.2) | 4/101 | 4.0 | 3.0 (1.0, 8.9) | 5.2 | 3.8 (1.9, 7.5) |
2+ | 3/20 | 15.0 | 12.4 (3.0, 52.3) | 3/16 | 18.8 | 12.1 (3.1, 47.7) | 7/15 | 46.7 | 63.4 (21.0, 19.8) | 25.5 | 23.2 (11.3, 47.6) |
No. of primaries 5 | |||||||||||
1 | 14/581 | 2.4 | n/a | 8/644 | 1.2 | 1.0 | 20/1495 | 1.4 | 1.0 | 1.3 | 1.0 |
2 | 0/14 | 0 | 6/80 | 7.5 | 6.5 (2.2, 19.1) | 4/73 | 5.5 | 4.3 (1.4, 12.9) | 6.5 | 5.4 (2.5, 11.6) | |
3+ | 0/1 | 0 | 5/23 | 21.7 | 22.1 (6.6, 74.2) | 7/18 | 38.9 | 46.9 (16.5, 133.5) | 29.3 | 32.4 (14.7, 71.2) | |