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Table 6 The effect of SHMT C1420T,CBS C699T,CBS C1080T,MSA2756G,MTRR A66G polymorphic genotype on Hcy concentration

From: Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women

Genotype Plasma total Hcy(μ mol/L)a p b
  Cases Controls  
SHMT 1420CC 16.44 ± 17.69 14.99 ± 7.12 0.15
SHMT 1420CT 18.74 ± 12.32 11.04 ± 4.64 0.01**
SHMT 1420TT 14.86 ± 6.06 10.02 ± 2.97 0.014*
  p = 0.021*(TT&CC) p = 0.033*(TT&CC)  
CBS 699CC 14.47 ± 3.32 10.36 ± 5.12 0.01**
CBS 699CT 21.62 ± 13.08 11.20 ± 3.56 0.011*
CBS 699TT 19.52 ± 15.89 15.47 ± 6.82 0.019*
  p = 0.01**(TT&CC) p = 0.028**(TT&CC)  
CBS 1080CC 15.76 ± 7.17 9.28 ± 3.30 0.01**
CBS 1080CT 16.64 ± 10.95 11.67 ± 2.36 0.021*
CBS 1080TT 20.99 ± 16.89 16.45 ± 9.45 0.01**
  p = 0.01**(TT&CC) p = 0.01**(TT&CC)  
MS 2756AA 12.23 ± 5.16 10.71 ± 3.30 0.121
MS 2756AG 20.43 ± 15.32 13.39 ± 7.91 0.01**
MS 2756GG 21.15 ± 23.30 19.97 ± 12.88 0.042*
  p = 0.01**(GG&AA) p = 0.002**(GG&AA)  
MTRR 66AA 17.52 ± 5.69 10.88 ± 2.67 0.01**
MTRR 66AG 15.83 ± 10.99 12.67 ± 5.13 0.040*
MTRR 66GG 23.70 ± 23.51 22.20  
  p = 0.031*(GG&AA)   
  1. aValues are expressed as mean ± SD.
  2. b*p < 0.05, **p < 0.01 compared with wild genotype.