Hereditary Cancer in Clinical Practice

Table 6 The effect of SHMT C1420T,CBS C699T,CBS C1080T,MSA2756G,MTRR A66G polymorphic genotype on Hcy concentration

From: Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women

Genotype	Plasma total Hcy(μ mol/L)^a		p ^b
	Cases	Controls
SHMT 1420CC	16.44 ± 17.69	14.99 ± 7.12	0.15
SHMT 1420CT	18.74 ± 12.32	11.04 ± 4.64	0.01^**
SHMT 1420TT	14.86 ± 6.06	10.02 ± 2.97	0.014^*
	p = 0.021^(TT&CC*)	p = 0.033^(TT&CC*)
CBS 699CC	14.47 ± 3.32	10.36 ± 5.12	0.01^**
CBS 699CT	21.62 ± 13.08	11.20 ± 3.56	0.011^*
CBS 699TT	19.52 ± 15.89	15.47 ± 6.82	0.019^*
	p = 0.01^*(TT&CC*)	p = 0.028^*(TT&CC*)
CBS 1080CC	15.76 ± 7.17	9.28 ± 3.30	0.01^**
CBS 1080CT	16.64 ± 10.95	11.67 ± 2.36	0.021^*
CBS 1080TT	20.99 ± 16.89	16.45 ± 9.45	0.01^**
	p = 0.01^*(TT&CC*)	p = 0.01^*(TT&CC*)
MS 2756AA	12.23 ± 5.16	10.71 ± 3.30	0.121
MS 2756AG	20.43 ± 15.32	13.39 ± 7.91	0.01^**
MS 2756GG	21.15 ± 23.30	19.97 ± 12.88	0.042^*
	p = 0.01^*(GG&AA*)	p = 0.002^*(GG&AA*)
MTRR 66AA	17.52 ± 5.69	10.88 ± 2.67	0.01^**
MTRR 66AG	15.83 ± 10.99	12.67 ± 5.13	0.040^*
MTRR 66GG	23.70 ± 23.51	22.20
	p = 0.031^(GG&AA*)

^aValues are expressed as mean ± SD.
^b*p < 0.05, **p < 0.01 compared with wild genotype.

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