Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada

Table 3 Total patient population screened

(A)Number of Breast Cancer Cases in Families
	Total	5 BC in family	4 BC in family	3 BC in family	2 BC in family	1 BC in family	0 BC in family
Female Unilateral Breast	126	19	25	31	39	12	0
Female Multiple Primary Breast	24	1	4	2	12	5	0
Male Breast	12	0	0	1	4	7	0
Breast and Ovarian	4	1	1	0	1	1	0
Ovarian	9	0	2	2	2	1	2
Total screened	175	21	32	36	58	26	2
*PALB2* mutations*	2	0	0	2	0	0	0
B) Proximity to Breast Cancer Cases in Families
		Total	FDR with BC	SDR with BC	TDR with BC	No relatives with BC
Female Unilateral Breast		126	79	28	7	12
Female Multiple Primary Breast		24	11	5	3	5
Male Breast		12	2	1	2	7
Breast and Ovarian		4	2	0	1	1
Ovarian		9	4	2	1	2
Total screened		175	98	36	14	27
*PALB2* mutations*		2	1	0	1	0

*Only the two definitely deleterious mutations were included in these tables. BC = breast cancer; FDR = first degree relative; SDR = second degree relative; TDR = third degree relative.

ISSN: 1897-4287