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Table 1 Characteristics of 175 probands with clinical diagnoses of female unilateral breast cancer, female multiple primary breast cancer, male breast cancer or ovarian cancer

From: Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada

  Female unilateral Female multiple primary Male breast cancer Ovarian cancer
Number of probands: 126 24 12 13*
Age at Diagnosis (N) (%) (N) (%) (N) (%) (N) (%)
20-29 7 5.6 0 0 0 0 1 7.7
30-39 26 20.6 5 20.8 0 0 1 7.7
40-49 44 34.9 13 54.2 3 25.0 5 38.5
50-59 30 23.8 6 25.0 2 16.7 0 0
60-69 16 12.7 0 0 3 25.0 5 38.5
70 and over 3 2.3 0 0 4 33.3 1 7.7
Mean (years) 47.1 43.4 60.8 51.3
Range (years) 23-78 31-58 43-76 23-76
Mean time from diagnosis (years) 4.7 12.4 1.8 10.3
Ethnicity** (N) (%) (N) (%) (N) (%) (N) (%)
British Isles 47 37.3 8 33.3 6 50.0 5 38.5
French Canadian 27 21.4 5 20.8 1 8.3 5 38.5
Other European 19 15.1 7 29.2 2 16.6 2 15
Ashkenazi Jewish 8 6.3 1 4.2 0 0 0 0
Asian 4 3.2 0 0 1 8.3 0 0
Mixed Ethnicity 16 12.7 3 12.5 1 8.3 0 0
Other or unknown 5 4.0 0 0 1 8.3 1 7.7
  1. *Includes 4 probands affected with both breast and ovarian cancer.
  2. **All self-reported ethnicities from the side of the family eligible for BRCA1 and BRCA2 sequencing based on Ontario guidelines.