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Table 1 Characteristics of 175 probands with clinical diagnoses of female unilateral breast cancer, female multiple primary breast cancer, male breast cancer or ovarian cancer

From: Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada

 

Female unilateral

Female multiple primary

Male breast cancer

Ovarian cancer

Number of probands:

126

24

12

13*

Age at Diagnosis

(N)

(%)

(N)

(%)

(N)

(%)

(N)

(%)

20-29

7

5.6

0

0

0

0

1

7.7

30-39

26

20.6

5

20.8

0

0

1

7.7

40-49

44

34.9

13

54.2

3

25.0

5

38.5

50-59

30

23.8

6

25.0

2

16.7

0

0

60-69

16

12.7

0

0

3

25.0

5

38.5

70 and over

3

2.3

0

0

4

33.3

1

7.7

Mean (years)

47.1

43.4

60.8

51.3

Range (years)

23-78

31-58

43-76

23-76

Mean time from diagnosis (years)

4.7

12.4

1.8

10.3

Ethnicity**

(N)

(%)

(N)

(%)

(N)

(%)

(N)

(%)

British Isles

47

37.3

8

33.3

6

50.0

5

38.5

French Canadian

27

21.4

5

20.8

1

8.3

5

38.5

Other European

19

15.1

7

29.2

2

16.6

2

15

Ashkenazi Jewish

8

6.3

1

4.2

0

0

0

0

Asian

4

3.2

0

0

1

8.3

0

0

Mixed Ethnicity

16

12.7

3

12.5

1

8.3

0

0

Other or unknown

5

4.0

0

0

1

8.3

1

7.7

  1. *Includes 4 probands affected with both breast and ovarian cancer.
  2. **All self-reported ethnicities from the side of the family eligible for BRCA1 and BRCA2 sequencing based on Ontario guidelines.