TY - JOUR AU - Moreira-Nunes, Caroline Aquino AU - Barros, Mariceli Baia Leão AU - do Nascimento Borges, Bárbara AU - Montenegro, Raquel Carvalho AU - Lamarão, Leticia Martins AU - Ribeiro, Helem Ferreira AU - Bona, Amanda Braga AU - Assumpção, Paulo Pimentel AU - Rey, Juan Antonio AU - Pinto, Giovanny Rebouças AU - Burbano, Rommel Rodriguez PY - 2014 DA - 2014/08/13 TI - Genetic screening analysis of patients with hereditary diffuse gastric cancer from northern and northeastern Brazil JO - Hereditary Cancer in Clinical Practice SP - 18 VL - 12 IS - 1 AB - Hereditary diffuse gastric cancer (HDGC) is a hereditary autosomal inherited syndrome associated with CDH1 germline mutations. In Brazil, gastrointestinal tumors are among the most prevalent tumor types and constitute a serious public health problem, especially in the northern and northeastern regions. This study aimed to investigate germline mutations, methylation pattern and genomic rearrangements in the CDH1 gene and quantitative changes in the DNA of HDGC patients in northern and northeastern Brazil. SN - 1897-4287 UR - https://doi.org/10.1186/1897-4287-12-18 DO - 10.1186/1897-4287-12-18 ID - Moreira-Nunes2014 ER -