Figure 2

CNV results for WWOX deletion in fBC patient. (A) CNV profile from Cyto2.7 M array data defining the region of deletion including the genomic state (where 0 = the normal two copies and -1 = one less copy; (B) Location of the deletion within the gene and with respect to the CN assays used in validating the variant; and (C) TaqMan CN Validation assay showing the deletion represented by Hs03945201_cn: note the normal two copies of this region identified in the control, confirmation of the aberrant one copy in the fBC patient and the CN range bars associated with the three technical replicates used to validate the CNVs.