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Table 2 IHC/MSI profile according to type of cancer

From: The Norwegian PMS2 founder mutation c.989-1G > T shows high penetrance of microsatellite instable cancers with normal immunohistochemistry

Tumour type

IHC performed

PMS2 expressed

Loss of PMS2 expression

MSI performed

MSS

MSI high

MSI low

Colorectal

11

9

2

9

 

9

 

Gastric

2

2

0

2

 

1

1

Endometrial

4

3

1

3

 

2

1

Prostate

1

1

0

1

  

1

Ovarian

1

1

0

1

 

1

 

Breast

3

3

0

3

1

1

1

Sarcoma

1

1

0

1

 

1

 

Renal

1

1

0

1

1

  

Sum

24

21 (87.5%)

3

21

2

15 (71.4%)

4 (19.0%)