Table 1 Revised Bethesda guidelines for testing colorectal tumors for microsatellite instability (MSI)
From: Germline deletions in the EPCAM gene as a cause of Lynch syndrome – literature review
1 | Colorectal cancer diagnosed below 50 years of age. |
2 | Presence of synchronous, metachronous colorectal, or other Lynch syndrome-associated* tumors, regardless of age. |
3 | Colorectal cancer with high-MSI*, histology diagnosed in a patient who is less than 60 years of age. |
4 | Colorectal cancer diagnosed with one or more first-degree relatives with Lynch syndrome – associated tumors*, with one of the cancers being diagnosed under age 50 years. |
5 | Colorectal cancer diagnosed in two or more first or second degree relatives with Lynch syndrome-associated tumors* regardless of age |