Table 2 Risk of neoplastic disease manifestation in individual organs in cases of hamartomatous polyposis syndromes
Organ | Cumulative risk (%) of cancer development in individual syndromes of hamartomatous polyposis | ||
|---|---|---|---|
Juvenile polyposis syndrome | Peutz - Jeghers` syndrome | PHTS | |
Thyroid gland | 3-10 | ||
Breasts | (8% risk by age 40, 45% by age 70). | 25-50 | |
Stomach | 21 | 29 | |
Pancreas | Two cases | 36 | |
Small intestine | 13 | ||
Large bowel | 9%-68% (17%-22% by age 25 | 57 (9% ba age 40) | |
Kidneys | 2 | ||
Urinary bladder | 3 | ||
Uterus | 9 | 6 | |
Uterine cervix | 10 | 3 | |
Ovaries | 21 | 2 | |
Testes | 9 | ||