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Table 1 Genes preconditioning syndromes of hamartomatous polyposis

From: Hamartomatous polyposis syndromes

Gene BMPR1A SMAD4 PTEN STK11
Name Bone morphogenetic protein receptor, type Ia Mothers against decapentaplegic, drosophila, homolog of, 4 Phosphatase and tensin homologue Serine/threonine protein kinase 11
Function of the protein receptor signalling protein phosphatase kinase
MIM *601299 *600993 *601728 *602216
Chromosome 10q22.3 18q21 10q23.31 19q13.3
Size 168.5 kbp 38.5 kbp 108 kbp 23 kbp
Exons 13 11 9 10
Amino acids 532 552 403 433
Transcript (bp) 3613 8365 9007 3276
Mass of protein 60 kDa 60 kDa 47 kDa 48.6 kDa
  1. An asterisk (*) before MIM entry number indicates a gene.