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Table 1 Logistic regression and Kaplan-Meier analysis

From: The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients

Logistic regression model (n = 139)   Analysis endpoint - CRC Analysis endpoint - Adenomas
APT5A1 SNP: Genotype Total n (%) Cancer free (n) CRC (n) Adenomas (n) OR (95% CI) p-value Kaplan-Meier analysis p-value* OR (95% CI) p-value Kaplan-Meier analysis p-value*
rs13381709: CC 59 (42) 51 8 44 1.0   0.3183 1.0   0.2561
  CT 57 (41) 46 11 42 1.52 (0.56-4.12) 0.406 0.95 (0.42-2.19) 0.913
  TT 23 (17) 22 1 13 0.29 (0.03-2.46) 0.256   0.44 (0.16-1.22) 0.115  
rs1800636: CC 59 (42) 51 8 44 1.0   0.3183 1.0   0.2561
  CT 57 (41) 46 11 42 1.52 (0.56-4.12) 0.406 0.95 (0.42-2.19) 0.913
  TT 23 (17) 22 1 13 0.29 (0.03-2.46) 0.256   0.44 (0.16-1.22) 0.115  
rs1800637: TT 58 (42) 50 8 44 1.0   0.5385 1.0   0.2362
  TC 56 (40) 46 10 41 1.36 (0.49-3.74) 0.553 0.87 (0.37-2.02) 0.746
  CC 25 (18) 23 2 14 0.54 (0.11-2.76) 0.462   0.40 (0.15-1.09) 0.074  
rs1800639: GG 59 (42) 51 8 44 1.0   0.3183 1.0   0.2561
  GT 57 (41) 46 11 42 1.52 (0.56-4.12) 0.406 0.95 (0.42-2.19) 0.913
  TT 23 (17) 22 1 13 0.29 (0.03-2.46) 0.256   0.44 (0.16-1.22) 0.115  
  TT 57 (41) 49 8 44 1.0   0.3183 1.0   0.2561
  TC 57 (41) 46 11 42 1.52 (0.56-1.12) 0.406 0.95 (0.42-2.19) 0.913
  CC 23 (17) 22 1 13 0.29 (0.03-2.46) 0.256 0.44 (0.16-1.22) 0.115
  Failed genotyping 2 (1)          
rs2298787: TT 57 (41) 50 7 42 1.0   0.3208 1.0   0.4143
  TC 59 (42) 47 12 44 1.82 (0.66-5.03) 0.245 1.05 (0.46-2.41) 0.913
  CC 23 (17) 22 1 13 0.32 (0.04-2.80) 0.306   0.46 (0.17-1.28) 0.138  
rs2578187: GG 114 (82) 99 15 78 1.0   0.9719 1.0   0.5744
  GA 24 (17) 19 5 20 1.74 (0.56-5.35) 0.336 2.31 (0.74-7.24) 0.152
  AA 1 (1) 1 0 1 - -   - -  
rs2578189: CC 89 (64) 78 11 67 1.0   0.0014 1.0   0.3898
  CT 45 (32) 38 7 28 1.31 (0.47-3.64) 0.609 0.54 (0.25-1.17) 0.118
  TT 5 (4) 3 2 4 4.73 (0.71-31.52) 0.109   1.31 (0.14-12.38) 0.812  
rs7244921: TT 59 (42) 51 8 44 1.0   0.3183 1.0   0.2561
  TC 57 (41) 46 11 42 1.52 (0.56-4.12) 0.406 0.95 (0.42-2.19) 0.913
  CC 23 (17) 22 1 13 0.29 (0.03-2.46) 0.256   0.44 (0.16-1.22) 0.115  
rs8088881: TT 58 (42) 50 8 44 1.0   0.3179 1.0   0.2493
  TC 57 (41) 46 11 42 1.49 (0.55-4.04) 0.429 0.89 (0.38-2.07) 0.788
  CC 23 (17) 22 1 13 0.28 (0.03-2.41) 0.249 0.41 (0.15-1.15) 0.090
  Failed genotyping 1 (1)          
rs8089150: AA 57 (41) 50 7 42 1.0   0.3208 1.0   0.4143
  AG 59 (42) 47 12 44 0.82 (0.66-5.03) 0.245 1.05 (0.46-2.41) 0.913
  GG 23 (17) 22 1 13 0.32 (0.04-2.80) 0.306   0.46 (0.17-1.28) 0.138  
rs8092674: CC 59 (42) 51 8 44 1.0   0.3183 1.0   0.2561
  CT 57 (41) 46 11 42 1.52 (0.56-4.12) 0.406 0.95 (0.42-2.19) 0.913
  TT 23 (17) 22 1 13 0.29 (0.03-2.46) 0.256   0.44 (0.16-1.22) 0.115  
rs8093880: CC 57 (41) 49 8 43 1.0   0.3322 1.0   0.3575
  CT 55 (40) 45 10 42 1.36 (0.49-3.75) 0.551 1.05 (0.44-2.50) 0.909
  TT 23 (17) 22 1 13 0.28 (0.03-2.36) 0.241 0.42 (0.15-1.18) 0.099
  Failed genotyping 4 (3)          
rs8094902: TT 59 (42) 51 8 44 1.0   0.3183 1.0   0.2561
  TC 57 (41) 46 11 42 1.52 (0.56-4.12) 0.406 0.95 (0.42-2.19) 0.913
  CC 23 (17) 22 1 13 0.29 (0.03-2.46) 0.256   0.44 (0.16-1.22) 0.115  
rs8095031: TT 59 (42) 51 8 44 1.0   0.3234 1.0   0.2221
  TC 57 (41) 46 11 42 1.52 (0.56-4.12) 0.406 0.95 (0.42-2.19) 0.913
  CC 22 (16) 22 1 12 0.30 (0.04-2.58) 0.275   0.41 (0.15-1.14) 0.087  
  Failed genotyping 1 (1)          
rs8095608: AA 58 (42) 51 7 43 1.0   0.3183 1.0   0.3738
  AG 58 (42) 46 12 43 1.90 (0.68-5.24) 0.214 1.0 (0.44-2.30) 1.000
  GG 22 (16) 21 1 12 0.35 (0.04-2.99) 0.336 0.42 (0.15-1.17) 0.096
  Failed genotyping 1 (1)          
  1. *Log-Rank p-value.
  2. Demographics of the genotype frequencies in Australian FAP patients with CRC, patients with adenomas and cancer/adenoma free individuals. Logistic regression model was used to test risk of CRC associated with each SNP, while Kaplan-Meier estimator analysis was used to test association between age of diagnosis of CRC/adenomas and genotype. Two different analysis was performed; one using CRC as endpoint of analysis and one using adenomas as endpoint of analysis.