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Figure 3 | Hereditary Cancer in Clinical Practice

Figure 3

From: The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients

Figure 3

Kaplan-Meier estimated by location of APC mutation. A) Using CRC as end-point of analysis: The graph shows the effect the location of the APC mutation has on age of diagnosis of CRC in Dutch FAP patients. A significant difference is observed between the attenuated (APC AFAP), intermediate (APC, 53 years) and severe (MCR, 40 years) polyposis phenotype; Log-rank p ≤ 0.0001. B) Using adenomas as end-point of analysis: The graph shows the effect the location of the APC mutation has on age of diagnosis of adenomas in Dutch FAP patients. A significant difference is observed between the attenuated (APC AFAP, 35 years), intermediate (APC, 24 years) and severe (MCR, 15 years) polyposis phenotype; Log-rank p ≤ 0.0001.

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