Kaplan-Meier estimated by adenoma phenotype using CRC as end-point of analysis. The graph shows the effect the adenoma phenotype has on age of diagnosis of CRC in Dutch FAP patients. The adenoma-categories are: AFAP = <100 adenomas and Classic FAP = 100 or more adenomas. A significant difference is observed between adenoma phenotype and age of diagnosis of CRC (Log-rank p = 0.0256), even though there is no difference between ages of diagnosis of CRC and adenoma phenotypes can be seen when 50% of the population is cancer free (AFAP = 55 years and Classic FAP = 54 years). An increased risk of CRC for patients in the Classic FAP compare to AFAP phenotype is observed: OR = 2.12, 95% CI = 1.14-3.92 and p = 0.017).