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Table 2 Relationship between inflammatory related sequence variants and prostate cancer risk among men of African Descent

From: The impact of genetic variants in inflammatory-related genes on prostate cancer risk among men of African Descent: a case control study

Genes

dbSNP ID location predicted function

Genotype

Cases n (%)

Controls n (%)

Unadjusted OR (95%CI)†

Adjusted OR (95%CI)†

p-valueǂ

p trend

Bonferroni correction

IL1R2

rs11886877

GG

87 (31.2)

211 (39.4)

1.00 (referent)

1.00 (referent)

0.034

0.010

NS

 

Intron 1

GA

149 (53.4)

265 (49.5)

1.36 (0.99, 1.88)

1.35 (0.92,1.98)

0.058

  
  

AA

43 (15.4)

59 (11.1)

1.77 (1.11, 2.82)

1.92 (1.11, 3.32)

0.017

  
  

GA + AA

192 (68.8)

324 (60.6)

1.44 (1.06, 1.95)

1.46 (1.01, 2.10)

0.021

  
  

AA vs (GG + GA)

  

1.47 (0.96,2.24)

1.61 (0.98,2.63)

0.074

  

IL1A

rs17561

CC

195 (69.9)

358 (66.9)

1.00 (referent)

1.00 (referent)

0.025

0.108

NS

 

Exon 4

CA

82 (29.4)

155 (29.0)

0.97 (0.70,1.34)

1.01 (0.68,1.48)

0.858

  
 

Splicing

AA

2 (0.70)

22 (4.10)

0.17 (0.04, 0.72)

0.40 (0.08,1.83)

0.016

  
 

nsSNP

CA + AA

84 (30.1)

177 (33.1)

0.87 (0.64,1.20)

0.96 (0.66,1.40)

0.388

  
 

benign

AA vs (CC + CA)

  

0.17 (0.04, 0.72)

0.40 (0.09,1.82)

0.016

  

IL8RB

rs11574752

GG

230 (82.4)

435 (81.3)

1.00 (referent)

1.00 (referent)

0.011

0.784

NS

 

3′-UTR

GA

43 (15.4)

99 (18.5)

0.82 (0.55,1.21)

0.90 (0.56,1.40)

0.326

  
 

miRNA

AA

6 (2.20)

1 (0.20)

11.3 (1.36, 94.6)

38.4 (3.86, 382.8)

0.009

  
  

GA + AA

49 (17.6)

100 (18.7)

0.93 (0.64,1.35)

1.08 (0.69,1.70)

0.693

  
  

AA vs (GG + GA)

  

11.7 (1.40, 98.0)

39.2 (3.94, 390)

0.008

  

TNF

rs1800629

GG

171 (61.2)

368 (68.8)

1.00 (referent)

1.00 (referent)

0.047

0.087

NS

 

5′ near gene

GA

103 (37.0)

153 (28.6)

1.45 (1.06, 1.97)

1.54 (1.06, 2.24)

0.019

  
 

TFBS

AA

5 (1.80)

14 (2.60)

0.77 (0.27, 2.16)

1.30 (0.37,4.60)

0.619

  
  

GA + AA

108 (38.8)

167 (31.2)

1.39 (1.03, 1.90)

1.53 (1.06, 2.20)

0.032

  
  

AA vs (GG + GA)

  

0.68 (0.24,1.91)

1.13 (0.32,3.90)

0.462

  

TNF

rs673

GG

171 (61.3)

364 (68.0)

1.00 (referent)

1.00 (referent)

0.009

0.228

NS

 

5′ near gene

GA

106 (38.0)

156 (29.2)

1.45 (1.06, 2.00)

1.50 (1.04, 2.16)

0.018

  
 

TFBS

AA

2 (0.70)

15 (2.80)

0.28 (0.06, 1.26)

0.47 (0.09,2.40)

0.097

  
  

GA + AA

108 (39.1)

171 (32.0)

1.34 (0.99, 1.82)

1.43 (1.00, 2.05)

0.055

  
  

AA vs (GG + AG)

  

0.25 (0.06,1.10)

0.41 (0.08,2.07)

0.067

  

IL1A

rs2856836

AA

196 (70.3)

358 (66.9)

1.00 (referent)

1.00 (referent)

0.024

0.089

NS

 

3′-UTR

AG

81 (29.0)

155 (29.0)

0.96 (0.69,1.32)

0.99 (0.67,1.45)

0.776

  
 

miRNA

GG

2 (0.70)

22 (4.10)

0.17 (0.04, 0.71)

0.40 (0.09,1.82)

0.016

  
  

AG + GG

83 (29.7)

177 (33.1)

0.86 (0.63,1.17)

0.94 (0.65,1.36)

0.333

  
  

GG vs (AA + AG)

  

0.17 (0.04, 0.72)

0.40 (0.09,1.82)

0.016

  

IL10RA

rs4252243

GG

134 (48.4)

268 (50.4)

1.00 (referent)

1.00 (referent)

0.066

0.168

NS

 

5′ near gene

GA

115 (41.5)

234 (44.0)

0.98 (0.72,1.32)

0.83 (0.58,1.18)

0.893

  
 

TFBS

AA

28 (10.1)

30 (5.60)

1.86 (1.07, 3.24)

1.62 (0.82, 3.21)

0.028

  
  

GA + AA

143 (51.6)

264 (49.6)

1.08 (0.81,1.44)

0.91 (0.64,1.28)

0.605

  
  

AA vs (GG + GA)

  

1.88 (1.10, 3.21)

1.77 (0.91, 3.43)

0.021

  
  1. ǂOn a separate line before the text regarding the chi-square test p-values state the following:
  2. †Boldface odd ratios (ORs) and 95% confidence interval (CI) indicate a significant relationship between the selected SNPs and prostate cancer risk.
  3. From top to bottom within the column, the chi-square test p-values were used to determine the difference in the genotype frequencies between cases and controls for the overall, minor/major versus major/major genotypes, as well as the dominant (i.e., minor/minor versus major/major), co-dominant (minor/minor + major/minor versus major/major), and recessive genetic models (minor/minor versus major/major + major/minor). P-values generated from the Fisher’s Exact test (in italics) were calculated when expected genotype counts were < 5 for either cases or controls. Statistically significant p-values are marked in bold face.
  4. Abbreviations: UTR, untranslated region; TFBS, transcription factor binding site; miRNA, microRNA binding site; NS, non-significant.
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287