dbSNPID | Gene | Location functional consequence | NCBI nucleotide change (major > minor allele)† | NCBI minor allele frequency (MAF) for African-Americans | NCBI major/major genotype n (%) for African-Americans | NCBI major/minor genotype n (%) for African-Americans | NCBI minor/minor genotype n (%) for African-Americans | Current study nucleotide change (major > minor allele) | Current study MAF n(%) for African-Americans | Current study major/major genotype n (%) for African-Americans | Current study major/minor genotype n (%) for African-Americans | Current study minor/minor genotype n (%) for African-Americans | Overall χ2P-value comparing genotypes from individuals of African Descent as reported in NCBI versus the current study†† |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs1058867 ǂ | IL10RB | UTR'3 miRNA | G > A | A = 37.9 | 26 (42.0) | 25 (40.3) | 11 (17.7) | G > A | A = 33.9 | 239 (44.6) | 229 (42.9) | 67 (12.5) | 0.514 |
rs1071676 ǂ | IL1B | UTR'3 miRNA | G > C | C = 14.6 | 19 (79.2) | 3 (12.5) | 2 (8.3) | G > C | C = 16.1 | 378 (70.7) | 142 (26.5) | 15 (2.80) | 0.106 |
rs11123902 ǂ | IL1R2 | Intron 1 | A > C | C = 31.8 | 10 (45.5) | 10 (45.5) | 2 (9.10) | A > C | C = 30.7 | 258 (48.2) | 225 (42.1) | 52 (9.70) | 0.949 |
rs1126579 ǂ | IL8RB | UTR'3 miRNA | C > T | T = 14.5 | 46 (74.2) | 14 (22.6) | 2 (3.20) | G > A† | A = 13.8 | 402 (75.1) | 118 (22.1) | 15 (2.80) | 0.886 |
rs1143627 ǂ | IL1B | Near gene 5' TFBS | C > T | T = 37.5 | 12 (50.0) | 6 (25.0) | 6 (25.0) | G > A† | A = 39.6 | 194 (36.3) | 256 (48.2) | 83 (15.5) | 0.063 |
rs1143634 ǂ | IL1B | Exon 4 Splicing | C > T | T = 12.9 | 47 (75.8) | 14 (22.6) | 1 (1.60) | G > A† | A = 15.5 | 381 (71.2) | 142 (26.5) | 12 (2.3) | 0.833 |
rs11574752 ǂ | IL8RB | UTR'3 miRNA | G > A | A = 10.4 | 19 (79.2) | 5 (20.8) | 0(0.00) | G > A | A = 9.40 | 435 (81.3) | 99 (18.5) | 1 (0.20) | 0.798 |
rs11886877 | IL1R2 | Intron 1 | --- | --- | --- | --- | --- | G > A | A = 35.8 | 211 (39.4) | 265 (49.5) | 59 (11.1) | |
rs12135247 ǂǂ | RNASEL | UTR'3 TFBS, miRNA | T > C | C = 16.3 | 33 (67.3) | 16 (32.7) | 0 (0.00) | A > G† | G = 17.9 | 368 (68.8) | 142 (26.5) | 25 (4.70) | 0.226 |
rs12328606 ǂǂ | IL1R2 | Near gene 5' TFBS | C > T | T = 11.2 | 38 (77.6) | 11 (22.4) | 0 (0.00) | G > A† | A = 13.5 | 405 (75.7) | 116 (21.7) | 14 (2.60) | 0.798 |
rs1304037 ǂ | IL1A | UTR'3 miRNA | A > G | G = 39.6 | 8 (33.3) | 13 (54.2) | 3 (12.5) | A > G | G = 41.1 | 191 (35.7) | 248 (46.4) | 96 (17.9) | 0.760 |
rs16944 ǂ | IL1B | Near gene 5' TFBS | A > G | G = 39.0 | 18 (30.5) | 36 (61.0) | 5 (8.50) | A > G | G = 45.1 | 156 (29.2) | 275 (51.4) | 104 (19.4) | 0.108 |
rs17561 ǂ | IL1A | Exon 4 Splicing, nsSNP, benign | G > T | T = 15.3 | 44 (71.0) | 17 (27.4) | 1 (1.60) | C > A† | A = 18.6 | 358 (66.9) | 155 (29.0) | 22 (4.10) | 0.698 |
rs1799964 ǂ | TNF | Near gene 5' TFBS | T > C | C = 12.9 | 46 (74.2) | 16 (25.8) | 0 (0.00) | A > G† | G = 16.5 | 374 (69.9) | 145 (27.1) | 16 (3.00) | 0.492 |
rs1800587 ǂ | IL1A | UTR'5 TFBS, Splicing | C > T | T = 39.1 | 9 (39.1) | 10 (43.5) | 4 (17.4) | G > A† | A = 41.8 | 183 (34.2) | 257 (48.0) | 95 (17.8) | 0.885 |
rs1800629 ǂ | TNF | Near gene 5' TFBS | G > A | A = 13.7 | 46 (74.2) | 15 (24.2) | 1 (1.60) | G > A | A = 16.9 | 368 (68.8) | 153 (28.6) | 14 (2.60) | 0.752 |
rs1800871 ǂ | IL10 | Near gene 5' TFBS | C > T | T = 36.3 | 28 (45.2) | 23 (37.1) | 11 (17.7) | G > A† | A = 40.7 | 188 (35.0) | 258 (48.0) | 89 (17.0) | 0.219 |
rs1800872 ǂǂ | IL10 | Near gene 5' TFBS | A > C | A = 50.0 C = 50.0 | 5 (21.7) | 13 (56.6) | 5 (21.7) | C > A† | A = 40.7 | 188 (35.0) | 258 (48.0) | 89 (17.0) | 0.874 |
rs1800893 ǂ | IL10 | Near gene 5' TFBS | G > A | A = 37.1 | 22 (35.5) | 34 (54.8) | 6 (9.70) | G > A | A = 36.4 | 216 (40.4) | 248 (46.4) | 71 (13.2) | 0.419 |
rs1800896 ǂ | IL10 | Near gene 5' TFBS | A > G | G = 40.5 | 7 (33.3) | 11 (52.4) | 3 (14.3) | A > G | G = 33.3 | 243 (45.4) | 228 (42.6) | 64 (12.0) | 0.491 |
rs2192752 ǂ | IL1R1 | Near gene 5' TFBS | A > C | C = 4.80 | 56 (90.3) | 6 (9.70) | 0 (0.00) | A > C | C = 5.60 | 477 (89.1) | 56 (10.5) | 2 (0.40) | 1.000 |
rs2227532 ǂ | IL8 | Near gene 5' TFBS | T > C | C = 9.70 | 50 (80.6) | 12 (19.4) | 0 (0.00) | A > G† | G = 8.60 | 448 (83.7) | 82 (15.3) | 5 (1.00) | 0.690 |
rs2227538 ǂ | IL8 | UTR'5 TFBS, Splicing | C > T | T = 17.7 | 41 (66.1) | 20 (32.3) | 1 (1.60) | G > A† | A = 23.2 | 323 (60.4) | 176 (32.9) | 36 (6.70) | 0.291 |
rs2227545 ǂ | IL8 | UTR'3 miRNA | A > C | C = 8.70 | 19 (82.6) | 4 (17.4) | 0 (0.00) | A > C | C = 8.50 | 449 (83.9) | 81 (15.1) | 5 (1.00) | 0.812 |
rs2229113 ǂ | IL10RA | Exon 7 nsSNP, probably damaging | G > A | A = 20.5 | 14 (63.7) | 7 (31.8) | 1 (4.50) | G > A | A = 18.8 | 355 (66.4) | 159 (29.7) | 21 (3.90) | 0.782 |
rs2834167 ǂ | IL10RB | Exon 2 Splicing, nsSNP, benign | A > G | G = 16.9 | 44 (71.0) | 15 (24.2) | 3 (4.80) | A > G | G = 11.0 | 423 (79.1) | 106 (19.8) | 6 (1.10) | 0.050 |
rs2856836 ǂ | IL1A | UTR'3 miRNA | T > C | C = 17.4 | 16 (69.6) | 6 (26.1) | 1 (4.30) | A > G† | G = 18.6 | 358 (66.9) | 155 (29.0) | 22 (4.10) | 1.000 |
rs3135932 ǂ | IL10RA | Exon 5 Splicing, nsSNP, benign | A > G | G = 2.10 | 23 (95.8) | 1 (4.20) | 0 (0.00) | A > G | G = 2.60 | 508 (95.0) | 26 (4.80) | 1 (0.20) | 1.000 |
rs315951 ǂ | IL1RN | UTR'3 miRNA | C > G | G = 47.9 | 8 (33.3) | 9 (37.5) | 7 (29.2) | C > G | G = 48.0 | 144 (26.9) | 268 (50.1) | 123 (23.0) | 0.482 |
rs3738579 ǂ | RNASEL | UTR'5 TFBS, Splicing | T > C | C = 16.7 | 14 (66.7) | 7 (33.3) | 0 (0.00) | A > G† | G = 12.3 | 411 (76.8) | 116 (21.7) | 8 (1.50) | 0.474 |
rs3917225 ǂ | IL1R1 | Near gene 5' TFBS | A > G | G = 12.3 | 49 (80.3) | 9 (14.8) | 3 (4.90) | A > G | G = 9.10 | 438 (81.9) | 97 (18.1) | 0 (0.00) | 0.001 |
rs4073 ǂ | IL8 | Near gene 5' TFBS | A > T | T = 26.6 | 34 (54.8) | 23 (37.1) | 5 (8.10) | T > A | A = 20.9 | 335 (62.6) | 176 (32.9) | 24 (4.50) | 0.262 |
rs4141134 ǂǂ | IL1R2 | Near gene 5' | T > C | C = 11.2 | 39 (79.6) | 9 (18.4) | 1 (2.00) | A > G† | G = 13.7 | 399 (74.6) | 125 (23.4) | 11 (2.00) | 0.660 |
rs4251961 ǂ | IL1RN | Near gene 5' TFBS | T > C | C = 20.2 | 37 (59.7) | 25 (40.3) | 0 (0.00) | A > G† | G = 17.9 | 367 (68.6) | 145 (27.1) | 23 (4.30) | 0.035 |
rs4252243 ǂ | IL10RA | Near gene 5' TFBS | C > T | T = 32.5 | 9 (45.0) | 9 (45.0) | 2 (10.0) | G > A† | A = 27.5 | 271 (50.7) | 234 (43.7) | 30 (5.60) | 0.522 |
rs4674257 ǂǂ | IL8RB | Near gene 5' TFBS | G > A | A = 25.0 | 14 (58.3) | 8 (33.3) | 2 (8.30) | G > A | A = 20.1 | 347 (64.9) | 161 (30.10) | 27 (5.00) | 0.468 |
rs4674259 ǂ | IL8RB | UTR'5 TFBS | A > G | G = 23.9 | 12 (52.2) | 11 (47.8) | 0 (0.00) | A > G | G = 20.0 | 349 (65.0) | 158 (30.0) | 28 (5.00) | 0.176 |
rs486907 ǂ | RNASEL | Exon 1 nsSNP, benign | G > A | A = 16.7 | 16 (66.7) | 8 (33.3) | 0 (0.00) | G > A | A = 13.2 | 402 (75.1) | 125 (23.4) | 8 (1.50) | 0.528 |
rs6726713 ǂǂ | IL1R2 | Near gene 5' TFBS | C > T | T = 11.2 | 38 (77.6) | 11 (22.4) | 0 (0.00) | G > A† | A = 12.1 | 417 (78.0) | 106 (19.8) | 12 (2.20) | 0.689 |
rs673 ǂ | TNF | Near gene 5' TFBS | G > A | A = 13.7 | 45 (72.6) | 17 (27.4) | 0 (0.00) | G > A | A = 17.4 | 364 (68.0) | 156 (29.2) | 15 (2.80) | 0.546 |
rs8178433 ǂ | IL10RB | Near gene 5' TFBS | T > G | G = 12.9 | 46 (74.2) | 16 (25.8) | 0 (0.00) | A > C† | C = 12.4 | 408 (76.3) | 121 (22.6) | 6 (1.10) | 0.811 |
rs949963 ǂ | IL1R1 | Near gene 5' TFBS | G > A | A = 31.1 | 31 (50.8) | 22 (36.1) | 8 (13.1) | G > A | A = 33.1 | 249 (46.5) | 218 (40.8) | 68 (12.7) | 0.771 |
rs9610 ǂ | IL10RA | UTR'3 miRNA | A > G | G = 41.9 | 20 (32.3) | 32 (51.6) | 10 (16.1) | A > G | G = 33.9 | 237 (44.3) | 233 (43.5) | 65 (12.2) | 0.184 |
rs999788 ǂ | IL10RB | Near gene 5' TFBS | C > T | T = 19.5 | 40 (67.8) | 15 (25.4) | 4 (6.80) | G > A† | A = 12.4 | 410 (76.6) | 117 (21.9) | 8 (1.50) | 0.026 |