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Table 1 Summary of register data from MMR South American Lynch syndrome families

From: Mutation spectrum in South American Lynch syndrome families

South American Institutions

Total number of patients/families

MMR mutation carriers

% of MMR mutation carriers

Mean age at CRC diagnosis

Mean age at endometrial cancer diagnosis

Hospital Italiano (Buenos Aires, Argentina)

28

14

50.0

44.3 (SD 6.2)

46.3 (SD 5.5)

Hospital de las Fuerzas Armadas (Montevideo, Uruguay)

25

7

28.0

35.1 (SD 7.6)

41.5 (SD 8.3)

Clinica Las Condesa (Santiago, Chile)

50

20

40.0

35.7 (SD 10.7)

41.1 (SD 8.8)

Barretos Cancer Hospitala (Barretos, Brazil)

23

15

65.2

39.4 (SD 13.8)

49.8 (SD 5.3)

Colombiac

13

8

61.5

NA

NA

Southeastern Brazilb

128

35

27.3

42.3 (SD 11.4)

48.8 (SD 2.4)

Total

267

99

37.1

  
  1. aMLPA analysis included, bValentin et al. 2011 [3] and Rossi et al. 2002 [5], cGiraldo et al. 2005 [2] and Alonso-Espinaco et al. 2011 [11], NA Information not available, MMR mismatch-repair genes, SD standard deviation, CRC colorectal cancer.