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Hereditary Cancer in Clinical Practice

Open Access

HOXB13 mutations and prostate cancer in Poland

  • Wojciech Kluźniak1,
  • Dominika Wokołorczyk1,
  • Jan Lubiński1 and
  • Cezary Cybulski1
Hereditary Cancer in Clinical Practice201210(Suppl 4):A30

Published: 10 December 2012


Prostate CancerRelative RiskMissense MutationSusceptibility GeneProstate Cancer Patient

Recently, HOXB13 has been established as a prostate cancer susceptibility gene in North America, with a relative risk associated with a single missense mutation of about 20. Ewing et al., sequenced over 200 genes in a prostate cancer linkage region at 17q21-22 among 94 probands of prostate cancer families, and found a recurrent mutation in the HOXB13 gene (G84E) in four families. The mutation co-segregated with prostate cancer. The geographical and ethnic extent of this founder allele has not yet been determined. We assayed for the presence of the G84E mutation in 3515 prostate cancer patients and 2604 controls from Poland. The G84E mutation predisposes to prostate cancer in Poland. We expect that the G84E founder mutation might be present in other Slavic populations.

Authors’ Affiliations

Department of Genetics and Pathomorphology of the Pomeranian Medical University, Szczecin, Poland


© Kluźniak et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.