Volume 10 Supplement 3

Annual Conference on Hereditary Cancers 2011

Open Access

Selenium and the risk of cancer of the lung and larynx. A case-control study from a region with low selenium

  • Katrzyna Jaworska1, 2Email author,
  • Satish Gupta1, 2,
  • Katarzyna Durda1,
  • Magdalena Muszynska1,
  • Grzegorz Sukiennicki1,
  • Elżbieta Jaworowska3,
  • Tomasz Grodzki4,
  • Mieczysław Sulikowski5,
  • Piotr Woloszczyk6,
  • Janusz Wójcik4,
  • Jakub Lubiński3,
  • Cezary Cybulski1,
  • Tadeusz Dębniak1,
  • Marcin Lener1,
  • Steven A Narod7,
  • Ping Sun7,
  • Jan Lubiński1 and
  • Anna Jakubowska1
Hereditary Cancer in Clinical Practice201210(Suppl 3):A7


Published: 20 April 2012

Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer.

Among lung cancer cases, the mean selenium level was 63.2 µg/l, compared to a mean level of 74.7 µg/l for their matched controls (p < 0.0001). Among laryngeal cancer cases, the mean selenium level was 64.8 µg/l, compared to a mean level of 76.3 µg/l for their matched controls (p < 0.0001). Compared to a serum selenium value in the lowest of four categories (≤ 60 µg/l) a selenium level in the highest category (> 80 µg/l) was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.24 (95% CI 0.10 to 0.59; p = 0.002) for laryngeal cancer. In four selenoproteins studied here we found a modest associations of genetic variants in GPX1 and GPX4 with lung and TXNRD2 with laryngeal cancer risk.

In this region of endemic low selenium level, there is a strong inverse association between the level of serum selenium and the risks of lung and laryngeal cancer.

Authors’ Affiliations

International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University
Postgraduate School of Molecular Medicine, Warsaw Medical University
Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University
Department of General Thoracic Surgery, Pomeranian Medical University
Maxillofacial Surgery, Pomeranian Medical University
Department of Toxicology and Molecular Pathobiochemistry, Pomeranian Medical University
Women’s College Research Institute


© Jaworska et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.