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Hereditary Cancer in Clinical Practice

Open Access

A case of late breast cancer metastases to both suprarenal glands 28 years after mastectomy

  • T Banasiewicz1Email author,
  • Ł Krokowicz1,
  • M Biczysko1,
  • M Janicka-Jedyńska2,
  • A Pławski3,
  • J Paszkowski1,
  • P Gronek4,
  • B Stawny1 and
  • M Drews1
Hereditary Cancer in Clinical Practice201210(Suppl 3):A1

Published: 20 April 2012


Breast CancerAdrenal GlandBRCA2 GeneRadical MastectomyBreast Cancer Metastasis

We present an extremely rare case of late metastases of breast cancer to both suprarenal glands 28 years after mastectomy. The patient originally underwent Patey’s radical mastectomy of the left breast. In the follow-up, metastases were detected in the skin of the thorax and labia majora and were subsequently resected. During the most recent hospitalization metastases to both adrenal glands were detected (PET-CT, MRI) and removed. In genetic examination the entire coding sequences of BRCA1 and BRCA2 gene were screened for mutation by direct PCR product sequencing as described before by Gorski et al. No BRCA1 and BRCA2 gene mutations were found.

Histological examination revealed breast cancer metastasis to the adrenal glands. In our opinion our case can be the latest described metastases of breast cancer. The described case was an early stage of primary cancer (T1N0M0). Patients after breast cancer resection should still be followed up for late metastases. Late metastases including atypical sites should always be suspected regardless of time from initial presentation. The correlations between mutation and metastases of breast cancer needs to be discussed.

Authors’ Affiliations

Department of General, Gastroenterological and Endocrinological Surgery, Poznan University of Medical Sciences, Poland
Department of Clinical Pathology, Poznan University of Medical Sciences, Poland
Institute of Human Genetics, Polish Academy of Sciences Poznan, Poland
Department of Physiology, University School of Physical Education, Poznan, Poland


© Banasiewicz et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.