Table 1 Clinical criteria for testing for CDH1 germline mutations[40]
From: Familial gastric cancer: detection of a hereditary cause helps to understand its etiology
• | 1 diffuse gastric cancer case below age 40, or |
• | 2 gastric cancer cases in a family, one confirmed diffuse gastric cancer below age 50, or |
• | 3 confirmed diffuse gastric cancer cases in 1st or 2nd degree relatives independent of age, or |
• | Personal or family history of diffuse gastric cancer and lobular breast cancer, with one diagnosis below age 50 |