From: DNA and RNA analyses in detection of genetic predisposition to cancer
GENE LOCALISATION | PREDISPOSITION TO MALIGNANCIES | PENETRANCE* |
---|---|---|
Rb1[2] 13q14 | retinoblastoma | up to 90% |
BRCA1[3] 17q21 | breast cancer | up to 80% |
BRCA2[3] 13q13 | ovarian cancer | |
prostate cancer | ||
colon cancer | ||
VHL[4] 3p25 | haemangioblastoma of the | up to 80% |
cerebellum and retina | ||
kidney cancer | ||
pheochromocytoma | ||
MSH2[5] 2p21 | colon cancer | up to 90% |
MLH1[5] 3p22 | endometrial cancer | for male |
MSH6[5] 2p16 | cancer of the stomach, | up to 70% |
cancer of the biliary tract | for female [6] | |
small bowel cancer | ||
ovarian cancer |