Skip to main content

Table 3 Association between chemokine associated SNPs and prostate cancer risk, stratified by racial ethnic group

From: Chemokine Ligand 5 (CCL5) and chemokine receptor (CCR5) genetic variants and prostate cancer risk among men of African Descent:a case-control study

Genes

dbSNP ID

Location

Genotype

Unadjusted

Unadjusted

Age-adjusted

Age-adjusted

P-value

P trend

P-vlue

P-trend

  

predicted function

 

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

US men

US men

Jamaican men

Jamaican men

    

US men

Jamaican men

US men

Jamaican men

    

CCR5

rs1799988

5’UTR

AA

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.063

0.076

0.085

0.034

  

TFBS

AG

0.95 (0.62, 1.44)

1.26 (0.66, 2.40)

0.68 (0.42, 1.12)

1.23 (0.60, 2.52)

0.808

 

0.484

 
   

GG

1.58 (0.99, 2.49)

2.25 (1.08, 4.71)

1.06 (0.60, 1.85)

2.23 (0.99, 5.00)

0.053

 

0.031

 
   

AG+GG

1.15 (0.79, 1.68)

1.56 (0.86, 2.82)

0.80 (0.52, 1.26)

1.55 (0.81, 2.98)

0.453

 

0.142

 
   

GG vs (AA+AG)

1.62 (1.08, 2.42)

1.96 (1.04, 3.70)

1.28 (0.78, 2.12)

1.98 (0.98, 3.98)

0.02

 

0.037

 

CCL5

rs2107538

5' near gene

GG

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.003

0.002

0.286

0.116

  

TFBS

GA

0.54 (0.36, 0.80)

0.75 (0.40, 1.40)

0.67 (0.42, 1.08)

0.82 (0.40, 1.64)

0.003

 

0.375

 
   

AA

0.48 (0.28, 0.82)

0.53 (0.24, 1.16)

0.53 (0.28, 1.01)

0.52 (0.22, 1.22)

0.007

 

0.116

 
   

AG+AA

0.52 (0.36, 0.76)

0.68 (0.38, 1.23)

0.63 (0.40, 0.99)

0.72 (0.37, 1.40)

0.001

 

0.204

 
   

AA vs (GG+GA)

0.68 (0.42, 1.11)

0.64 (0.32, 1.26)

0.66 (0.37, 1.20)

0.58 (0.28, 1.24)

0.125

 

0.192

 

CCL5

rs2280789

Intron 1

AA

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.039

0.018

0.508

0.823

  

TFBS

AG

0.60 (0.40, 0.90)

1.20 (0.66, 2.18)

0.60 (0.37, 0.97)

1.48 (0.76, 2.89)

0.015

 

0.549

 
   

GG

0.62 (0.24, 1.56)

0.59 (0.18, 1.89)

1.00 (0.34, 2.99)

0.42 (0.12, 1.46)

0.309

 

0.373

 
   

AG+GG

0.60 (0.41, 0.89)

1.06 (0.61, 1.86)

0.64 (0.40, 1.01)

1.18 (0.63, 2.20)

0.011

 

0.82

 
   

GG vs (AA+AG)

0.72 (0.28, 1.82)

0.55 (0.18, 1.80)

1.14 (1.12, 1.18)

0.36 (0.10, 1.27)

0.488

 

0.313

 

CCL5

rs3817655

Intron 2

GG

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0

0.003

0.275

0.11

  

TFBS

GA

0.44 (0.29, 0.65)

0.72 (0.38, 1.34)

0.49 (0.30, 0.80)

0.74 (0.36, 1.50)

<0.0001

 

0.302

 
   

AA

0.56 (0.34, 0.92)

0.53 (0.24, 1.16)

0.54 (0.29, 1.02)

0.50 (0.22, 1.20)

0.022

 

0.115

 
   

GA+AA

0.46 (0.32, 0.68)

0.66 (0.36, 1.20)

0.51 (0.32, 0.80)

0.66 (0.34, 1.28)

<0.0001

 

0.167

 
   

AA vs (GG+GA)

0.88 (0.55, 1.40)

0.66 (0.34, 1.28)

0.80 (0.46, 1.42)

0.61 (0.28, 1.27)

0.577

 

0.22

 

CCL25

rs2032887

Exon 3

AA

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.084

0.034

0.474

0.379

  

ESE or ESS

AG

0.67 (0.46, 0.99)

1.42 (0.80, 2.48)

0.70 (0.44, 1.11)

1.54 (0.82, 2.88)

0.404

 

0.225

 
  

nsSNP

GG

0.61 (0.29, 1.28)

1.10 (0.36, 3.38)

0.57 (0.22, 1.42)

0.84 (0.24, 2.88)

0.196

 

0.86

 
  

probably damaging

AG+GG

0.66, (0.46, 0.96)

1.37 (0.80, 2.36)

0.68 (0.44, 1.05)

1.42 (0.78, 2.60)

0.027

 

0.253

 
  

missense R>H

GG vs (AA+AG)

0.71 (0.34, 1.47)

0.93 (0.32, 2.75)

0.65 (0.26, 1.60)

0.68 (0.20, 2.24)

0.357

 

0.898

 

CCR5

rs1799987

Intron 1

GG

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.197

0.951

0.107

0.041

  

TFBS

GA

1.29 (0.88, 1.92)

1.28 (0.68, 2.44)

0.89 (0.56, 1.44)

1.25 (0.61, 2.56)

0.191

 

0.442

 
   

AA

0.84 (0.48, 1.48)

2.18 (1.04, 4.58)

0.58 (0.29, 1.14)

2.20 (0.98, 4.94)

0.558

 

0.039

 
   

GA+AA

1.18 (0.80, 1.70)

1.56 (0.86, 2.82)

0.81 (0.52, 1.26)

1.55 (0.81, 2.98)

0.399

 

0.142

 
   

AA vs (GG+GA)

0.72 (0.44, 1.21)

1.88 (0.99, 3.56)

0.61 (0.32, 1.15)

1.92 (0.96, 3.88)

0.222

 

0.051

 

CCR7

rs3136685

Intron 1

AA

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.381

0.731

0.103

0.086

   

AG

1.32 (0.86, 2.02)

2.24 (0.98, 5.16)

1.58 (0.94, 2.66)

2.78 (1.09, 7.08)

0.197

 

0.056

 
   

GG

1.07 (0.65, 1.76)

2.38 (1.02, 5.58)

1.02 (0.56, 1.86)

2.52 (0.97, 6.52)

0.778

 

0.045

 
   

AG+GG

1.23 (0.82, 1.84)

2.3 (1.05, 5.07)

1.36 (0.83, 2.21)

2.66 (1.10, 6.42)

0.305

 

0.037

 
   

GG vs (AA+AG)

0.90 (0.59, 1.36)

1.28 (0.74, 2.25)

0.76 (0.46, 1.26)

1.16 (0.62, 2.15)

0.622

 

0.372

 

CCR7

rs3136687

Intron 1

AA

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.022

0.294

0.229

0.218

   

AG

1.42 (0.89, 2.24)

2.16 (0.84, 5.56)

1.47 (0.85, 2.54)

1.52 (0.53, 4.38)

0.133

 

0.11

 
   

GG

0.78 (0.46, 1.34)

2.20 (0.84, 5.69)

0.85 (0.45, 1.59)

1.34 (0.46, 3.96)

0.38

 

0.106

 
   

AG+GG

1.17 (0.76, 1.81)

2.18 (0.88, 5.38)

1.22 (0.72, 2.05)

1.44 (0.52, 3.98)

0.482

 

0.092

 
   

GG vs (AA+AG)

0.61 (0.40, 0.93)

1.17 (0.68, 2.02)

1.14 (1.12, 1.18)

0.94 (0.51, 1.75)

0.023

 

0.573

 

CCR9

rs1488371

Intron 2

CC

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.013

0.902

0.003

0.018

   

CA

0.94 (0.62, 1.40)

0.52 (0.26, 1.08)

0.88 (0.54, 1.42)

0.60 (0.26, 1.31)

0.747

 

0.08

 
   

AA

1.57 (0.50, 4.90)

---

0.92 (0.22, 3.80)

---

0.435

 

0.984

 
   

CA+AA

0.98 (0.66, 1.44)

0.46 (0.23, 0.94)

0.88 (0.54, 1.40)

0.48 (0.22, 1.04)

0.901

 

0.034

 
   

AA vs (CC + CA)

1.60 (0.52, 4.97)

---

0.95 (0.23, 4.00)

---

0.414

 

0.984

 

CXCR7

rs1045879

Exon 1

AA

1.00 (referent)

1.00 (referent)

1.00 (referent)

1.00 (referent)

0.065

0.038

0.459

0.762

  

synSNP

AG

1.54 (1.06, 2.26)

1.38 (0.77, 2.48)

1.30 (0.82, 2.04)

1.30 (0.68, 2.50)

0.025

 

0.279

 
  

L>L

GG

1.53 (0.84, 2.79)

0.86 (0.34, 2.16)

1.02 (0.47, 2.20)

0.74 (0.27, 2.04)

0.166

 

0.756

 
   

AG+GG

1.54 (1.07, 2.22)

1.24 (0.72, 2.14)

1.24 (0.80, 1.93)

1.15 (0.62, 2.10)

0.02

 

0.431

 
   

GG vs (AA+AG)

1.21 (0.69, 2.13)

0.76 (0.31, 1.84)

0.88 (0.42, 1.84)

0.67 (0.25, 1.80)

0.499

 

0.538

 
  1. Abbreviations: UTR, untranslated region; TFBS, transcription factor binding site; ESE, exonic splicing enhancers ; ESS, exonic splicing silencers; nsSNP, non-synonymous coding SNP; synSNP, synonymous SNP.
Back to article page

Hereditary Cancer in Clinical Practice

ISSN: 1897-4287