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Table 3 Association between chemokine associated SNPs and prostate cancer risk, stratified by racial ethnic group

From: Chemokine Ligand 5 (CCL5) and chemokine receptor (CCR5) genetic variants and prostate cancer risk among men of African Descent:a case-control study

Genes dbSNP ID Location Genotype Unadjusted Unadjusted Age-adjusted Age-adjusted P-value P trend P-vlue P-trend
   predicted function   OR (95%CI) OR (95%CI) OR (95%CI) OR (95%CI) US men US men Jamaican men Jamaican men
     US men Jamaican men US men Jamaican men     
CCR5 rs1799988 5’UTR AA 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.063 0.076 0.085 0.034
   TFBS AG 0.95 (0.62, 1.44) 1.26 (0.66, 2.40) 0.68 (0.42, 1.12) 1.23 (0.60, 2.52) 0.808   0.484  
    GG 1.58 (0.99, 2.49) 2.25 (1.08, 4.71) 1.06 (0.60, 1.85) 2.23 (0.99, 5.00) 0.053   0.031  
    AG+GG 1.15 (0.79, 1.68) 1.56 (0.86, 2.82) 0.80 (0.52, 1.26) 1.55 (0.81, 2.98) 0.453   0.142  
    GG vs (AA+AG) 1.62 (1.08, 2.42) 1.96 (1.04, 3.70) 1.28 (0.78, 2.12) 1.98 (0.98, 3.98) 0.02   0.037  
CCL5 rs2107538 5' near gene GG 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.003 0.002 0.286 0.116
   TFBS GA 0.54 (0.36, 0.80) 0.75 (0.40, 1.40) 0.67 (0.42, 1.08) 0.82 (0.40, 1.64) 0.003   0.375  
    AA 0.48 (0.28, 0.82) 0.53 (0.24, 1.16) 0.53 (0.28, 1.01) 0.52 (0.22, 1.22) 0.007   0.116  
    AG+AA 0.52 (0.36, 0.76) 0.68 (0.38, 1.23) 0.63 (0.40, 0.99) 0.72 (0.37, 1.40) 0.001   0.204  
    AA vs (GG+GA) 0.68 (0.42, 1.11) 0.64 (0.32, 1.26) 0.66 (0.37, 1.20) 0.58 (0.28, 1.24) 0.125   0.192  
CCL5 rs2280789 Intron 1 AA 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.039 0.018 0.508 0.823
   TFBS AG 0.60 (0.40, 0.90) 1.20 (0.66, 2.18) 0.60 (0.37, 0.97) 1.48 (0.76, 2.89) 0.015   0.549  
    GG 0.62 (0.24, 1.56) 0.59 (0.18, 1.89) 1.00 (0.34, 2.99) 0.42 (0.12, 1.46) 0.309   0.373  
    AG+GG 0.60 (0.41, 0.89) 1.06 (0.61, 1.86) 0.64 (0.40, 1.01) 1.18 (0.63, 2.20) 0.011   0.82  
    GG vs (AA+AG) 0.72 (0.28, 1.82) 0.55 (0.18, 1.80) 1.14 (1.12, 1.18) 0.36 (0.10, 1.27) 0.488   0.313  
CCL5 rs3817655 Intron 2 GG 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0 0.003 0.275 0.11
   TFBS GA 0.44 (0.29, 0.65) 0.72 (0.38, 1.34) 0.49 (0.30, 0.80) 0.74 (0.36, 1.50) <0.0001   0.302  
    AA 0.56 (0.34, 0.92) 0.53 (0.24, 1.16) 0.54 (0.29, 1.02) 0.50 (0.22, 1.20) 0.022   0.115  
    GA+AA 0.46 (0.32, 0.68) 0.66 (0.36, 1.20) 0.51 (0.32, 0.80) 0.66 (0.34, 1.28) <0.0001   0.167  
    AA vs (GG+GA) 0.88 (0.55, 1.40) 0.66 (0.34, 1.28) 0.80 (0.46, 1.42) 0.61 (0.28, 1.27) 0.577   0.22  
CCL25 rs2032887 Exon 3 AA 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.084 0.034 0.474 0.379
   ESE or ESS AG 0.67 (0.46, 0.99) 1.42 (0.80, 2.48) 0.70 (0.44, 1.11) 1.54 (0.82, 2.88) 0.404   0.225  
   nsSNP GG 0.61 (0.29, 1.28) 1.10 (0.36, 3.38) 0.57 (0.22, 1.42) 0.84 (0.24, 2.88) 0.196   0.86  
   probably damaging AG+GG 0.66, (0.46, 0.96) 1.37 (0.80, 2.36) 0.68 (0.44, 1.05) 1.42 (0.78, 2.60) 0.027   0.253  
   missense R>H GG vs (AA+AG) 0.71 (0.34, 1.47) 0.93 (0.32, 2.75) 0.65 (0.26, 1.60) 0.68 (0.20, 2.24) 0.357   0.898  
CCR5 rs1799987 Intron 1 GG 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.197 0.951 0.107 0.041
   TFBS GA 1.29 (0.88, 1.92) 1.28 (0.68, 2.44) 0.89 (0.56, 1.44) 1.25 (0.61, 2.56) 0.191   0.442  
    AA 0.84 (0.48, 1.48) 2.18 (1.04, 4.58) 0.58 (0.29, 1.14) 2.20 (0.98, 4.94) 0.558   0.039  
    GA+AA 1.18 (0.80, 1.70) 1.56 (0.86, 2.82) 0.81 (0.52, 1.26) 1.55 (0.81, 2.98) 0.399   0.142  
    AA vs (GG+GA) 0.72 (0.44, 1.21) 1.88 (0.99, 3.56) 0.61 (0.32, 1.15) 1.92 (0.96, 3.88) 0.222   0.051  
CCR7 rs3136685 Intron 1 AA 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.381 0.731 0.103 0.086
    AG 1.32 (0.86, 2.02) 2.24 (0.98, 5.16) 1.58 (0.94, 2.66) 2.78 (1.09, 7.08) 0.197   0.056  
    GG 1.07 (0.65, 1.76) 2.38 (1.02, 5.58) 1.02 (0.56, 1.86) 2.52 (0.97, 6.52) 0.778   0.045  
    AG+GG 1.23 (0.82, 1.84) 2.3 (1.05, 5.07) 1.36 (0.83, 2.21) 2.66 (1.10, 6.42) 0.305   0.037  
    GG vs (AA+AG) 0.90 (0.59, 1.36) 1.28 (0.74, 2.25) 0.76 (0.46, 1.26) 1.16 (0.62, 2.15) 0.622   0.372  
CCR7 rs3136687 Intron 1 AA 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.022 0.294 0.229 0.218
    AG 1.42 (0.89, 2.24) 2.16 (0.84, 5.56) 1.47 (0.85, 2.54) 1.52 (0.53, 4.38) 0.133   0.11  
    GG 0.78 (0.46, 1.34) 2.20 (0.84, 5.69) 0.85 (0.45, 1.59) 1.34 (0.46, 3.96) 0.38   0.106  
    AG+GG 1.17 (0.76, 1.81) 2.18 (0.88, 5.38) 1.22 (0.72, 2.05) 1.44 (0.52, 3.98) 0.482   0.092  
    GG vs (AA+AG) 0.61 (0.40, 0.93) 1.17 (0.68, 2.02) 1.14 (1.12, 1.18) 0.94 (0.51, 1.75) 0.023   0.573  
CCR9 rs1488371 Intron 2 CC 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.013 0.902 0.003 0.018
    CA 0.94 (0.62, 1.40) 0.52 (0.26, 1.08) 0.88 (0.54, 1.42) 0.60 (0.26, 1.31) 0.747   0.08  
    AA 1.57 (0.50, 4.90) --- 0.92 (0.22, 3.80) --- 0.435   0.984  
    CA+AA 0.98 (0.66, 1.44) 0.46 (0.23, 0.94) 0.88 (0.54, 1.40) 0.48 (0.22, 1.04) 0.901   0.034  
    AA vs (CC + CA) 1.60 (0.52, 4.97) --- 0.95 (0.23, 4.00) --- 0.414   0.984  
CXCR7 rs1045879 Exon 1 AA 1.00 (referent) 1.00 (referent) 1.00 (referent) 1.00 (referent) 0.065 0.038 0.459 0.762
   synSNP AG 1.54 (1.06, 2.26) 1.38 (0.77, 2.48) 1.30 (0.82, 2.04) 1.30 (0.68, 2.50) 0.025   0.279  
   L>L GG 1.53 (0.84, 2.79) 0.86 (0.34, 2.16) 1.02 (0.47, 2.20) 0.74 (0.27, 2.04) 0.166   0.756  
    AG+GG 1.54 (1.07, 2.22) 1.24 (0.72, 2.14) 1.24 (0.80, 1.93) 1.15 (0.62, 2.10) 0.02   0.431  
    GG vs (AA+AG) 1.21 (0.69, 2.13) 0.76 (0.31, 1.84) 0.88 (0.42, 1.84) 0.67 (0.25, 1.80) 0.499   0.538  
  1. Abbreviations: UTR, untranslated region; TFBS, transcription factor binding site; ESE, exonic splicing enhancers ; ESS, exonic splicing silencers; nsSNP, non-synonymous coding SNP; synSNP, synonymous SNP.