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Table 2 Association between chemokine associated SNPs and prostate cancer risk among men of African descent

From: Chemokine Ligand 5 (CCL5) and chemokine receptor (CCR5) genetic variants and prostate cancer risk among men of African Descent:a case-control study

Genes dbSNP ID Location Genotype Cases n (%) Controls n (%) Unadjusted Adjusted P-value P-trend FDR
   predicted function†     OR (95%CI) OR (95%CI)    
CCR5 rs1799988 5’UTR AA 85 (30.7) 194 (36.7) 1.00 (referent) 1.00 (referent) 0.005 0.0039 0.0682
   TFBS AG 107 (38.6) 227 (43.9) 1.08 (0.76, 1.52) 0.83 (0.55, 1.25) 0.676   
    GG 85 (30.7) 108 (20.4) 1.80 (1.23, 2.63) 1.38 (0.87, 2.17) 0.003   
    AG+GG 192 (69.3) 335 (63.3) 1.31 (0.96, 1.78) 1.01 (0.70, 1.46) 0.09   0.4823
    GG vs (AA+AG)    1.73 (1.24, 2.40) 1.52 (1.02, 2.26) 0.0013   0.0494
CCL5 rs2107538 5' near gene GG 111 (39.8) 150 (28.1) 1.00 (referent) 1.00 (referent) 0.002 0.001 0.0493
   TFBS GA 124 (44.4) 270 (50.6) 0.62 (0.45, 0.86) 0.72 (0.49, 1.06) 0.004   
    AA 44 (15.8) 114 (21.4) 0.52 (0.34, 0.80) 0.53 (0.32, 0.89) 0.003   
    GA+AA 168 (60.2) 384 (71.9) 0.59 (0.44, 0.80) 0.66 (0.46, 0.96) 0.0007   0.015
    AA vs (GG+GA)    0.83 (0.57, 1.20) 0.74 (0.47, 1.16) 0.057   0.4735
CCL5 rs3817655 Intron 2 GG 114 (41.0) 147 (27.5) 1.00 (referent) 1.00 (referent) 0.004 0.002 0.019
   TFBS GA 115 (41.4) 278 (52.0) 0.53 (0.38, 0.74) 0.57 (0.38, 0.84) 0.0002   
    AA 49 (17.6) 110 (20.5) 0.57 (0.38, 0.87) 0.54 (0.32, 0.89) 0.0009   
    GA+AA 164 (59.0) 388 (72.5) 0.54 (0.40, 0.74) 0.56 (0.39, 0.81) 0.0001   0.0038
    AA vs (GG+GA)    0.83 (0.57, 1.20) 0.74 (0.47, 1.16) 0.317   1
CCR7 rs3136685 Intron 1 AA 55 (19.7) 151 (28.3) 1.00 (referent) 1.00 (referent) 0.029 0.031 0.3078
    AG 139 (49.8) 237 (44.4) 1.61 (1.11, 2.34) 1.86 (1.18, 2.92) 0.012   
    GG 85 (30.5) 146 (27.3) 1.60 (1.06, 2.40) 1.39 (0.85, 2.28) 0.024   
    AG+GG 224 (80.3) 383 (71.7) 1.61 (1.13, 2.28) 1.66 (1.09, 2.54) 0.008   0.599
    GG vs (AA+AG)    1.16 (0.85, 1.60) 0.92 (0.62, 1.35) 0.348   0.1615
CCR7 rs3136687 Intron 1 AA 84 (30.1) 173 (32.4) 1.00 (referent) 1.00 (referent) 0.041 0.458 0.3523
    AG 153 (54.8) 249 (46.5) 1.26 (0.91, 1.76) 1.45 (0.97, 2.16) 0.161   
    GG 42 (15.1) 113 (21.1) 0.77 (0.49, 1.19) 0.96 (0.57, 1.62) 0.234   
    AG+GG 195 (69.9) 362 (67.6) 1.11 (0.81, 1.52) 1.14 (1.12, 1.16) 0.516   0.7159
    GG vs (AA+AG)    0.66 (0.45, 0.98) 0.76 (0.49, 1.20) 0.037   0.5092