Table 2 Association between chemokine associated SNPs and prostate cancer risk among men of African descent
Genes | dbSNP ID | Location | Genotype | Cases n (%) | Controls n (%) | Unadjusted | Adjusted | P-value | P-trend | FDR |
|---|---|---|---|---|---|---|---|---|---|---|
|  |  | predicted function†|  |  |  | OR (95%CI) | OR (95%CI) |  |  |  |
CCR5 | rs1799988 | 5’UTR | AA | 85 (30.7) | 194 (36.7) | 1.00 (referent) | 1.00 (referent) | 0.005 | 0.0039 | 0.0682 |
| Â | Â | TFBS | AG | 107 (38.6) | 227 (43.9) | 1.08 (0.76, 1.52) | 0.83 (0.55, 1.25) | 0.676 | Â | Â |
| Â | Â | Â | GG | 85 (30.7) | 108 (20.4) | 1.80 (1.23, 2.63) | 1.38 (0.87, 2.17) | 0.003 | Â | Â |
| Â | Â | Â | AG+GG | 192 (69.3) | 335 (63.3) | 1.31 (0.96, 1.78) | 1.01 (0.70, 1.46) | 0.09 | Â | 0.4823 |
| Â | Â | Â | GG vs (AA+AG) | Â | Â | 1.73 (1.24, 2.40) | 1.52 (1.02, 2.26) | 0.0013 | Â | 0.0494 |
CCL5 | rs2107538 | 5' near gene | GG | 111 (39.8) | 150 (28.1) | 1.00 (referent) | 1.00 (referent) | 0.002 | 0.001 | 0.0493 |
| Â | Â | TFBS | GA | 124 (44.4) | 270 (50.6) | 0.62 (0.45, 0.86) | 0.72 (0.49, 1.06) | 0.004 | Â | Â |
| Â | Â | Â | AA | 44 (15.8) | 114 (21.4) | 0.52 (0.34, 0.80) | 0.53 (0.32, 0.89) | 0.003 | Â | Â |
| Â | Â | Â | GA+AA | 168 (60.2) | 384 (71.9) | 0.59 (0.44, 0.80) | 0.66 (0.46, 0.96) | 0.0007 | Â | 0.015 |
| Â | Â | Â | AA vs (GG+GA) | Â | Â | 0.83 (0.57, 1.20) | 0.74 (0.47, 1.16) | 0.057 | Â | 0.4735 |
CCL5 | rs3817655 | Intron 2 | GG | 114 (41.0) | 147 (27.5) | 1.00 (referent) | 1.00 (referent) | 0.004 | 0.002 | 0.019 |
| Â | Â | TFBS | GA | 115 (41.4) | 278 (52.0) | 0.53 (0.38, 0.74) | 0.57 (0.38, 0.84) | 0.0002 | Â | Â |
| Â | Â | Â | AA | 49 (17.6) | 110 (20.5) | 0.57 (0.38, 0.87) | 0.54 (0.32, 0.89) | 0.0009 | Â | Â |
| Â | Â | Â | GA+AA | 164 (59.0) | 388 (72.5) | 0.54 (0.40, 0.74) | 0.56 (0.39, 0.81) | 0.0001 | Â | 0.0038 |
| Â | Â | Â | AA vs (GG+GA) | Â | Â | 0.83 (0.57, 1.20) | 0.74 (0.47, 1.16) | 0.317 | Â | 1 |
CCR7 | rs3136685 | Intron 1 | AA | 55 (19.7) | 151 (28.3) | 1.00 (referent) | 1.00 (referent) | 0.029 | 0.031 | 0.3078 |
| Â | Â | Â | AG | 139 (49.8) | 237 (44.4) | 1.61 (1.11, 2.34) | 1.86 (1.18, 2.92) | 0.012 | Â | Â |
| Â | Â | Â | GG | 85 (30.5) | 146 (27.3) | 1.60 (1.06, 2.40) | 1.39 (0.85, 2.28) | 0.024 | Â | Â |
| Â | Â | Â | AG+GG | 224 (80.3) | 383 (71.7) | 1.61 (1.13, 2.28) | 1.66 (1.09, 2.54) | 0.008 | Â | 0.599 |
| Â | Â | Â | GG vs (AA+AG) | Â | Â | 1.16 (0.85, 1.60) | 0.92 (0.62, 1.35) | 0.348 | Â | 0.1615 |
CCR7 | rs3136687 | Intron 1 | AA | 84 (30.1) | 173 (32.4) | 1.00 (referent) | 1.00 (referent) | 0.041 | 0.458 | 0.3523 |
| Â | Â | Â | AG | 153 (54.8) | 249 (46.5) | 1.26 (0.91, 1.76) | 1.45 (0.97, 2.16) | 0.161 | Â | Â |
| Â | Â | Â | GG | 42 (15.1) | 113 (21.1) | 0.77 (0.49, 1.19) | 0.96 (0.57, 1.62) | 0.234 | Â | Â |
| Â | Â | Â | AG+GG | 195 (69.9) | 362 (67.6) | 1.11 (0.81, 1.52) | 1.14 (1.12, 1.16) | 0.516 | Â | 0.7159 |
| Â | Â | Â | GG vs (AA+AG) | Â | Â | 0.66 (0.45, 0.98) | 0.76 (0.49, 1.20) | 0.037 | Â | 0.5092 |