Table 4 Distribution of CDK4 mutations with area of cancer and smoking status
From: Novel germline CDK4 mutations in patients with head and neck cancer
Region in gene | Mutations/change in amino acid | Area of cancer | Smoking status | |||
|---|---|---|---|---|---|---|
Oral cavity (N = 224) | Pharynx (N = 97) | Larynx (N = 59) | Non smoker (N = 238) | Smokers (N = 142) | ||
Exon 2 | g5051G > C | 24 | 19 | 06 | 19 | 30 |
Exon 2 | g5095G > C | 22 | 15 | 08 | 22 | 23 |
Intron 3 | g5427delA | 18 | 11 | 02 | 17 | 14 |
Exon 5 | g5906C > A, g5907C > G | 15 | 08 | 04 | 15 | 12 |
Exon 7 | g7320 A > C, g7321_23delTGA | 20 | 03 | 01 | 13 | 11 |
3′ UTR | g7121_7122insG | 27 | 12 | 07 | 22 | 24 |
3′ UTR | g7143delG | 23 | 05 | 02 | 12 | 18 |
Total | Â | 149 | 73 | 30 | 120 | 132 |
|  | p = 0.13 | p = 0.03 | ||||
| Â | OR 84.0, 95% CI (65.69 to 233.69) | OR 1.84, 95% CI (1.33 -2.54) | ||||